Seroatlas · Human Serome Atlas

MYRIP

Rab effector MyRIP

Also known as: DKFZp586F1018, exophilin-8, MYRIP_HUMAN, SLAC2-C, SLAC2C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NFW9
Gene
MYRIP
Ensembl
ENSG00000170011
Chromosome
3
Canonical length
859 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center,Golgi apparatus

OverviewNCBI Gene

Predicted to enable actin binding activity; myosin binding activity; and protein kinase A binding activity. Predicted to be involved in positive regulation of insulin secretion. Predicted to be located in several cellular components, including cytoplasmic vesicle; perinuclear region of cytoplasm; and photoreceptor outer segment. Predicted to be part of exocyst. Predicted to be active in cortical actin cytoskeleton. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

859 residues, UniProt reviewed canonical sequence.

>Q8NFW9|MYRIP
     1  MGRKLDLSGL TDDETEHVLQ VVQRDFNLRK KEEERLSELK QKLDEEGSKC SILSKHQQFV
    61  EHCCMRCCSP FTFLVNTKRQ CGDCKFNVCK SCCSYQKHEK AWVCCVCQQA RLLRAQSLEW
   121  FYNNVKSRFK RFGSAKVLKN LYRKHRLESG ACFDILGGSL FESNLENEGS ISGSDSTFYR
   181  QSEGHSVMDT LAVALRVAEE AIEEAISKAE AYGDSLDKQN EASYLRDHKE ELTEELATTI
   241  LQKIIRKQKS KSEQQVEEEP GWPHPQSCST KVADEGTSAS PGGYRAPAAL WRSQSAFSIT
   301  GEEALKTPPV EAPSRQPRDQ GQHPRAESAL PSWKSVDRLD ETNLAPVLQS PDGNWVALKD
   361  GAPPPTRLLA KPKSGTFQAL EVASSVASAY DEMGSDSEED FDWSEALSKL CPRSRALPRN
   421  PQPQPTQAQS SDQGPIAASP SSALSPNPEA MCSDSETSSA GSSREVGHQA RLSWLQRKAP
   481  RNPAAEKMRL HGELDVNFNP QLASRETSDS SEPEEAPHTT DRRARRWRRA RLGSEEPSKE
   541  PSSPSAQLRD LDTHQVSDDL SETDISNEAR DPQTLTDTTE EKRRNRLYEL AMKMSEKETS
   601  SGEDQESEPK TESENQKESL SSEDNSQSVQ EELKKKFSAV SLCNISTEVL KVINATEELI
   661  AGSTGPWESP QVPPDRQKGM FPRGTDQVRL DEQLTSLEEN VYLAAGTVYG LETQLTELED
   721  AARCIHSGTD ETHLADLEDQ VATAAAQVHH AELQISDIES RISALTIAGL NIAPCVRFTR
   781  RRDQKQRTQV QTIDTSRQQR RKLPAPPVKA EKIETSSVTT IKTFNHNFIL QGSSTNRTKE
   841  RKGTTKDLME PALESAVMY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MYRIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.57
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 35 nTPM
  • cerebral cortex: 25 nTPM
  • cerebellum: 13 nTPM
  • hippocampal formation: 12 nTPM
  • salivary gland: 12 nTPM
  • liver: 11 nTPM

Single-cell type

  • retinal pigment epithelial cells: 5,171 nCPM
  • pituicytes/fscs: 1,570 nCPM
  • choroid plexus epithelial cells: 1,276 nCPM
  • vascular endothelial cells: 564 nCPM
  • salivary acinar cells: 479 nCPM
  • cardiomyocytes: 478 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 44 nTPM
  • midbrain: 44 nTPM
  • amygdala: 41 nTPM
  • choroid plexus: 38 nTPM
  • basal ganglia: 37 nTPM
  • white matter: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0
gnomAD missense Z
0.73
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MYRIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MYRIP as an antibody target. Whether an autoantibody or antibody against MYRIP could matter depends on whether native MYRIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MYRIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MYRIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MYRIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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