Seroatlas · Human Serome Atlas

EXOC3L1

Exocyst complex component 3-like protein

Also known as: EX3L1_HUMAN, EXOC3L, FLJ35539, FLJ35587

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VI1
Gene: EXOC3L1
Ensembl: ENSG00000179044
Chromosome: 16
Canonical length: 746 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

Predicted to enable SNARE binding activity. Predicted to be involved in exocyst localization; exocytosis; and peptide hormone secretion. Predicted to be located in secretory granule. Predicted to be part of exocyst. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

746 residues, UniProt reviewed canonical sequence.

>Q86VI1|EXOC3L1
     1  MDSAAKDEMQ PALSPGPEWP EQERAEQLAR GAALKWASGI FYRPEQLARL GQYRSREVQR
    61  TCSLESRLKS VMQSYLEGVQ TGVWQLAQAI EVVQGTREAL SQARGLLQGM SQALQTLEPL
   121  RERVAQHKQL QALSHLLPRL RAVPAAVSHT QTLIDGQQFL EAYVSLRELE QLREDTWAPL
   181  GGLELPVFQG LDLLFEALGQ AVEAAAGAAG KLAREDPALL VAAVRVAEVE TGRTTPLGQV
   241  PRDWRQRCLR ALQEGLEQAH FGSPLLPAPG ALPGWLEALR VALPVELATA EALVAPCCPP
   301  QYNVVQLWAH TLHSGLRRSL QNLLAGPELE AADAFALLHW ALHVYLGQEM MGSLELGPEA
   361  DVSQLEPLLT LENIEQLEAT FVANIQASVS QWLQNALDGE VAEWGREHGP NTDPSGSYYS
   421  PMPAIVLQIL EENIRVASLV SESLQQRVHG MALSELGTFL RSFSDALIRF SRDHFRGKSM
   481  APHYVPYLLA ALNHKSALSS SVSVLQLDGA PSGALAPVEA ALDELQRRIY RLVLEALQAE
   541  LQPLFADLPS RQWLSSPELL QSVCERTGRF CRDFWRVRNP TVQLLLAEAE RAVVLQYLSA
   601  LMQGRLVCRG ADERTQAAER LRHDAAQLQQ LFLSLGLEEN AHCAPVLLAL RELLNLRDPA
   661  LLGLEVAGLR QQFPDVSEDH VSALLGLRGD LSREQHLAAL SSLQAALPPS PRASRRVLFS
   721  LVPAPALAPA SCLPSGSCAR ALLLAE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC3L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 44 nTPM

Expression across tissuesHPA

Tissue

spleen: 44 nTPM
lung: 9.6 nTPM
kidney: 7.2 nTPM
thyroid gland: 7 nTPM
adipose tissue: 6.1 nTPM
placenta: 5.5 nTPM

Single-cell type

lymphatic endothelial cells: 28 nCPM
ovarian stromal cells: 21 nCPM
peritubular myoid cells: 20 nCPM
vascular endothelial cells: 18 nCPM
granulosa cells: 15 nCPM
early primary spermatocytes: 12 nCPM

Immune cell

non-classical monocyte: 0.4 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

pons: 3.9 nTPM
cerebellum: 3.7 nTPM
cerebral cortex: 2.8 nTPM
medulla oblongata: 2.8 nTPM
amygdala: 2.7 nTPM
hypothalamus: 2.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

SNARE binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC3L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC3L1 as an antibody target. Whether an autoantibody or antibody against EXOC3L1 could matter depends on whether native EXOC3L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC3L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC3L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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