Seroatlas · Human Serome Atlas

RABEP2

Rab GTPase-binding effector protein 2

Also known as: FLJ23282, FRA, RABE2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H5N1
Gene: RABEP2
Ensembl: ENSG00000177548
Chromosome: 16
Canonical length: 569 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity and growth factor activity. Involved in regulation of cilium assembly. Located in Golgi apparatus; cytosol; and microtubule organizing center. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q9H5N1|RABEP2
     1  MAAAAPVAAD DDERRRRPGA ALEDSRSQEG ANGEAESGEL SRLRAELAGA LAEMETMKAV
    61  AEVSESTKAE AVAAVQRQCQ EEVASLQAIL KDSISSYEAQ ITALKQERQQ QQQDCEEKER
   121  ELGRLKQLLS RAYPLDSLEK QMEKAHEDSE KLREIVLPME KEIEELKAKL LRAEELIQEI
   181  QRRPRHAPSL HGSTELLPLS RDPSPPLEPL EELSGDGGPA AEAFAHNCDD SASISSFSLG
   241  GGVGSSSSLP QSRQGLSPEQ EETASLVSTG TLVPEGIYLP PPGYQLVPDT QWEQLQTEGR
   301  QLQKDLESVS RERDELQEGL RRSNEDCAKQ MQVLLAQVQN SEQLLRTLQG TVSQAQERVQ
   361  LQMAELVTTH KCLHHEVKRL NEENQGLRAE QLPSSAPQGS QQEQGEEESL PSSVPELQQL
   421  LCCTRQEARA RLQAQEHGAE RLRIEIVTLR EALEEETVAR ASLEGQLRVQ REETEVLEAS
   481  LCSLRTEMER VQQEQSKAQL PDLLSEQRAK VLRLQAELET SEQVQRDFVR LSQALQVRLE
   541  RIRQAETLEQ VRSIMDEAPL TDVRDIKDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABEP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

spleen: 49 nTPM
lymph node: 44 nTPM
prostate: 31 nTPM
small intestine: 28 nTPM
skin: 24 nTPM
appendix: 24 nTPM

Single-cell type

b-cells: 125 nCPM
paneth cells: 74 nCPM
rod photoreceptor cells: 56 nCPM
goblet cells: 49 nCPM
prostatic glandular cells: 49 nCPM
colonocytes: 49 nCPM

Immune cell

naive B-cell: 15 nTPM
memory B-cell: 12 nTPM
NK-cell: 5.5 nTPM
myeloid DC: 3.7 nTPM
gdT-cell: 3.5 nTPM
non-classical monocyte: 3.3 nTPM

Brain region

choroid plexus: 19 nTPM
medulla oblongata: 19 nTPM
basal ganglia: 15 nTPM
pons: 15 nTPM
midbrain: 14 nTPM
cerebral cortex: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABEP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABEP2 as an antibody target. Whether an autoantibody or antibody against RABEP2 could matter depends on whether native RABEP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABEP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABEP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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