Seroatlas · Human Serome Atlas

EXOC5

Exocyst complex component 5

Also known as: EXOC5_HUMAN, SEC10, SEC10L1, SEC10P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00471
Gene
EXOC5
Ensembl
ENSG00000070367
Chromosome
14
Canonical length
708 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

708 residues, UniProt reviewed canonical sequence.

>O00471|EXOC5
     1  MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI QELQIMDERI
    61  QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD EHISYVATKV CHLGDQLEGV
   121  NTPRQRAVEA QKLMKYFNEF LDGELKSDVF TNSEKIKEAA DIIQKLHLIA QELPFDRFSE
   181  VKSKIASKYH DLECQLIQEF TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA
   241  YLRNDIFEDA GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA
   301  EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI EVETGYLKSR
   361  SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG PSIDTHGETF LSQEVVVNLL
   421  QETKQAFERC HRLSDPSDLP RNAFRIFTIL VEFLCIEHID YALETGLAGI PSSDSRNANL
   481  YFLDVVQQAN TIFHLFDKQF NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL
   541  NCMIGQMKHI LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD
   601  TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV LHLFDTLHAL
   661  CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS ARLARHFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • testis: 10 nTPM
  • retina: 9.1 nTPM
  • adipose tissue: 8.4 nTPM
  • thymus: 8.1 nTPM
  • liver: 7.8 nTPM
  • spleen: 7.5 nTPM

Single-cell type

  • ependymal cells: 205 nCPM
  • early spermatids: 188 nCPM
  • early primary spermatocytes: 172 nCPM
  • choroid plexus epithelial cells: 150 nCPM
  • late spermatids: 148 nCPM
  • corticotrophs: 128 nCPM

Immune cell

  • basophil: 6.8 nTPM
  • total PBMC: 6.8 nTPM
  • myeloid DC: 6.3 nTPM
  • NK-cell: 6.3 nTPM
  • T-reg: 6.3 nTPM
  • eosinophil: 6.1 nTPM

Brain region

  • white matter: 27 nTPM
  • midbrain: 26 nTPM
  • choroid plexus: 26 nTPM
  • pons: 26 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.18
gnomAD pLI
1
gnomAD missense Z
2.34
DepMap mean gene effect
-0.51
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Exocyst complex component Sec10-like
  • Exocyst complex component Sec10, N-terminal
  • Exocyst complex component Sec10-like, alpha-helical bundle
  • Exocyst complex component Sec10-like, alpha-helical bundle
  • Exocyst complex component Sec10, N-terminal

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC5 as an antibody target. Whether an autoantibody or antibody against EXOC5 could matter depends on whether native EXOC5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOC5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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