Seroatlas · Human Serome Atlas

NUF2

Kinetochore protein Nuf2

Also known as: CDCA1, CT106, NUF2_HUMAN, NUF2R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BZD4
Gene
NUF2
Ensembl
ENSG00000143228
Chromosome
1
Canonical length
464 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Kinetochore,Cytosol

OverviewNCBI Gene

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

464 residues, UniProt reviewed canonical sequence.

>Q9BZD4|NUF2
     1  METLSFPRYN VAEIVIHIRN KILTGADGKN LTKNDLYPNP KPEVLHMIYM RALQIVYGIR
    61  LEHFYMMPVN SEVMYPHLME GFLPFSNLVT HLDSFLPICR VNDFETADIL CPKAKRTSRF
   121  LSGIINFIHF REACRETYME FLWQYKSSAD KMQQLNAAHQ EALMKLERLD SVPVEEQEEF
   181  KQLSDGIQEL QQSLNQDFHQ KTIVLQEGNS QKKSNISEKT KRLNELKLSV VSLKEIQESL
   241  KTKIVDSPEK LKNYKEKMKD TVQKLKNARQ EVVEKYEIYG DSVDCLPSCQ LEVQLYQKKI
   301  QDLSDNREKL ASILKESLNL EDQIESDESE LKKLKTEENS FKRLMIVKKE KLATAQFKIN
   361  KKHEDVKQYK RTVIEDCNKV QEKRGAVYER VTTINQEIQK IKLGIQQLKD AAEREKLKSQ
   421  EIFLNLKTAL EKYHDGIEKA AEDSYAKIDE KTAELKRKMF KMST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • testis: 50 nTPM
  • bone marrow: 27 nTPM
  • thymus: 24 nTPM
  • lymph node: 17 nTPM
  • tonsil: 16 nTPM
  • appendix: 6.5 nTPM

Single-cell type

  • late primary spermatocytes: 308 nCPM
  • cardiomyocytes: 194 nCPM
  • early primary spermatocytes: 159 nCPM
  • epicardial cells: 114 nCPM
  • monocyte progenitors: 90 nCPM
  • erythrocyte progenitors: 86 nCPM

Immune cell

  • T-reg: 4.3 nTPM
  • memory CD4 T-cell: 1.8 nTPM
  • NK-cell: 1.8 nTPM
  • basophil: 1.4 nTPM
  • eosinophil: 1.3 nTPM
  • gdT-cell: 1.2 nTPM

Brain region

  • white matter: 2.4 nTPM
  • pons: 2.3 nTPM
  • medulla oblongata: 2.2 nTPM
  • thalamus: 2.2 nTPM
  • basal ganglia: 1.9 nTPM
  • cerebral cortex: 1.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NUF2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 84 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on NUF2 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.37
DepMap mean gene effect
-1.72
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Kinetochore protein Nuf2, N-terminal
  • Nuf2, N-terminal domain superfamily
  • Nuf2 family

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUF2 as an antibody target. Whether an autoantibody or antibody against NUF2 could matter depends on whether native NUF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/NUF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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