Seroatlas · Human Serome Atlas

PMF1

Polyamine-modulated factor 1

Also known as: PMF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6P1K2
Gene: PMF1
Ensembl: ENSG00000160783
Chromosome: 1
Canonical length: 205 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables leucine zipper domain binding activity and transcription coactivator activity. Involved in chromosome segregation. Located in Golgi apparatus; kinetochore; and nucleoplasm. Part of MIS12/MIND type complex. Implicated in bladder carcinoma and urinary bladder cancer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q6P1K2|PMF1
     1  MAEASSANLG SGCEEKRHEG SSSESVPPGT TISRVKLLDT MVDTFLQKLV AAGSYQRFTD
    61  CYKCFYQLQP AMTQQIYDKF IAQLQTSIRE EISDIKEEGN LEAVLNALDK IVEEGKVRKE
   121  PAWRPSGIPE KDLHSVMAPY FLQQRDTLRR HVQKQEAENQ QLADAVLAGR RQVEELQLQV
   181  QAQQQAWQAL HREQRELVAV LREPE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PMF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 106 nTPM
tongue: 84 nTPM
bone marrow: 70 nTPM
heart muscle: 67 nTPM
kidney: 61 nTPM
liver: 61 nTPM

Single-cell type

choroid plexus epithelial cells: 34 nCPM
oligodendrocytes: 33 nCPM
bergmann glia: 28 nCPM
oligodendrocyte progenitor cells: 24 nCPM
microglia: 20 nCPM
astrocytes: 19 nCPM

Immune cell

plasmacytoid DC: 96 nTPM
classical monocyte: 86 nTPM
total PBMC: 78 nTPM
T-reg: 76 nTPM
myeloid DC: 70 nTPM
intermediate monocyte: 61 nTPM

Brain region

white matter: 35 nTPM
medulla oblongata: 34 nTPM
basal ganglia: 30 nTPM
spinal cord: 29 nTPM
thalamus: 29 nTPM
cerebellum: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -1.11
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear MIS12/MIND complex subunit PMF1/Nnf1
Nnf1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PMF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PMF1 as an antibody target. Whether an autoantibody or antibody against PMF1 could matter depends on whether native PMF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PMF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PMF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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