Seroatlas · Human Serome Atlas

CLASRP

CLK4-associating serine/arginine rich protein

Also known as: CLASP, CLASR_HUMAN, SFRS16, SWAP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N2M8
Gene: CLASRP
Ensembl: ENSG00000104859
Chromosome: 19
Canonical length: 674 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be involved in RNA splicing and mRNA processing. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

674 residues, UniProt reviewed canonical sequence.

>Q8N2M8|CLASRP
     1  MWHEARKHER KLRGMMVDYK KRAERRREYY EKIKKDPAQF LQVHGRACKV HLDSAVALAA
    61  ESPVNMMPWQ GDTNNMIDRF DVRAHLDHIP DYTPPLLTTI SPEQESDERK CNYERYRGLV
   121  QNDFAGISEE QCLYQIYIDE LYGGLQRPSE DEKKKLAEKK ASIGYTYEDS TVAEVEKAAE
   181  KPEEEESAAE EESNSDEDEV IPDIDVEVDV DELNQEQVAD LNKQATTYGM ADGDFVRMLR
   241  KDKEEAEAIK HAKALEEEKA MYSGRRSRRQ RREFREKRLR GRKISPPSYA RRDSPTYDPY
   301  KRSPSESSSE SRSRSRSPTP GREEKITFIT SFGGSDEEAA AAAAAAAASG VTTGKPPAPP
   361  QPGGPAPGRN ASARRRSSSS SSSSSASRTS SSRSSSRSSS RSRRGGGYYR SGRHARSRSR
   421  SWSRSRSRSR RYSRSRSRGR RHSGGGSRDG HRYSRSPARR GGYGPRRRSR SRSHSGDRYR
   481  RGGRGLRHHS SSRSRSSWSL SPSRSRSLTR SRSHSPSPSQ SRSRSRSRSQ SPSPSPAREK
   541  LTRPAASPAV GEKLKKTEPA AGKETGAAKP KLTPQEKLKL RMQKALNRQF KADKKAAQEK
   601  MIQQEHERQE REDELRAMAR KIRMKERERR EKEREEWERQ YSRQSRSPSP RYSREYSSSR
   661  RRSRSRSRSP HYRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLASRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 19 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 19 nTPM
bone marrow: 18 nTPM
pancreas: 15 nTPM
ovary: 15 nTPM
skin: 15 nTPM
testis: 14 nTPM

Single-cell type

early primary spermatocytes: 128 nCPM
neutrophils: 116 nCPM
oligodendrocytes: 111 nCPM
pdcs: 108 nCPM
retinal ganglion cells: 97 nCPM
adrenal cortex cells: 91 nCPM

Immune cell

neutrophil: 5.5 nTPM
memory B-cell: 4.1 nTPM
eosinophil: 3.7 nTPM
naive B-cell: 3.4 nTPM
plasmacytoid DC: 3.2 nTPM
memory CD8 T-cell: 2.4 nTPM

Brain region

white matter: 25 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 20 nTPM
pons: 20 nTPM
midbrain: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.43
gnomAD missense Z: 2.63
DepMap mean gene effect: -0.28
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CLASRP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLASRP as an antibody target. Whether an autoantibody or antibody against CLASRP could matter depends on whether native CLASRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLASRP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLASRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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