Seroatlas · Human Serome Atlas

PIP4P2

Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Also known as: DKFZp762O076, PP4P2_HUMAN, TMEM55A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4L2
Gene: PIP4P2
Ensembl: ENSG00000155099
Chromosome: 8
Canonical length: 257 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

257 residues, UniProt reviewed canonical sequence.

>Q8N4L2|PIP4P2
     1  MAADGVDERS PLLSASHSGN VTPTAPPYLQ ESSPRAELPP PYTAIASPDA SGIPVINCRV
    61  CQSLINLDGK LHQHVVKCTV CNEATPIKNP PTGKKYVRCP CNCLLICKDT SRRIGCPRPN
   121  CRRIINLGPV MLISEEQPAQ PALPIQPEGT RVVCGHCGNT FLWMELRFNT LAKCPHCKKI
   181  SSVGSALPRR RCCAYITIGM ICIFIGVGLT VGTPDFARRF RATYVSWAIA YLLGLICLIR
   241  ACYWGAIRVS YPEHSFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIP4P2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 28 nTPM
heart muscle: 19 nTPM
cerebral cortex: 18 nTPM
blood vessel: 18 nTPM
hypothalamus: 17 nTPM
midbrain: 17 nTPM

Single-cell type

neutrophil progenitors: 501 nCPM
neutrophils: 413 nCPM
platelets: 361 nCPM
retinal pigment epithelial cells: 200 nCPM
megakaryocytes: 155 nCPM
hofbauer cells: 89 nCPM

Immune cell

neutrophil: 77 nTPM
classical monocyte: 12 nTPM
eosinophil: 11 nTPM
myeloid DC: 11 nTPM
total PBMC: 6.1 nTPM
plasmacytoid DC: 6 nTPM

Brain region

hypothalamus: 35 nTPM
white matter: 34 nTPM
choroid plexus: 34 nTPM
pons: 30 nTPM
thalamus: 28 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

5-bisphosphate 4-phosphatase activity
phosphatidylinositol-4

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PIP4P2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PIP4P2 as an antibody target. Whether an autoantibody or antibody against PIP4P2 could matter depends on whether native PIP4P2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PIP4P2 is annotated at the cell surface, where native PIP4P2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PIP4P2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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