Seroatlas · Human Serome Atlas

UFC1

Ubiquitin-fold modifier-conjugating enzyme 1

Also known as: HSPC155, UFC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y3C8
Gene
UFC1
Ensembl
ENSG00000143222
Chromosome
1
Canonical length
167 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

UFC1 is an E2-like conjugating enzyme for ubiquitin-fold modifier-1 (UFM1; MIM 610553) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

167 residues, UniProt reviewed canonical sequence.

>Q9Y3C8|UFC1
     1  MADEATRRVV SEIPVLKTNA GPRDRELWVQ RLKEEYQSLI RYVENNKNAD NDWFRLESNK
    61  EGTRWFGKCW YIHDLLKYEF DIEFDIPITY PTTAPEIAVP ELDGKTAKMY RGGKICLTDH
   121  FKPLWARNVP KFGLAHLMAL GLGPWLAVEI PDLIQKGVIQ HKEKCNQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UFC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
207 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 207 nTPM
  • fallopian tube: 197 nTPM
  • basal ganglia: 170 nTPM
  • choroid plexus: 168 nTPM
  • amygdala: 164 nTPM
  • epididymis: 161 nTPM

Single-cell type

  • esophageal apical cells: 775 nCPM
  • respiratory ciliated cells: 749 nCPM
  • late spermatids: 637 nCPM
  • fallopian tube ciliated cells: 596 nCPM
  • syncytiotrophoblasts: 552 nCPM
  • extravillous trophoblasts: 513 nCPM

Immune cell

  • T-reg: 275 nTPM
  • total PBMC: 268 nTPM
  • MAIT T-cell: 213 nTPM
  • memory B-cell: 210 nTPM
  • NK-cell: 209 nTPM
  • plasmacytoid DC: 207 nTPM

Brain region

  • hypothalamus: 95 nTPM
  • medulla oblongata: 82 nTPM
  • white matter: 76 nTPM
  • midbrain: 73 nTPM
  • cerebral cortex: 73 nTPM
  • spinal cord: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about UFC1.

Disease | AllUniProt

Conditions UFC1 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with spasticity and poor growth (NEDSG) MIM:618076

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with spasticity and poor growth

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
-0.39
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UFC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UFC1 as an antibody target. Whether an autoantibody or antibody against UFC1 could matter depends on whether native UFC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UFC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UFC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/UFC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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