GSTP1

Protein identityUniProt · HPA

UniProt accession

P09211

Gene

GSTP1

Ensembl

ENSG00000084207

Chromosome

11

Canonical length

210 aa

Protein class

Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Mitochondria,Cytosol

Quaternary structure

Homodimer

OverviewNCBI Gene

Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>P09211|GSTP1
     1  MPPYTVVYFP VRGRCAALRM LLADQGQSWK EEVVTVETWQ EGSLKASCLY GQLPKFQDGD
    61  LTLYQSNTIL RHLGRTLGLY GKDQQEAALV DMVNDGVEDL RCKYISLIYT NYEAGKDDYV
   121  KALPGQLKPF ETLLSQNQGG KTFIVGDQIS FADYNLLDLL LIHEVLAPGC LDAFPLLSAY
   181  VGRLSARPKL KAFLASPEYV NLPINGNGKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GSTP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

2,859 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GSTP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 61 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Kala-azar susceptibility 2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.85

gnomAD pLI

0.01

gnomAD missense Z

-0.33

DepMap mean gene effect

-0.2

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ regeneration
• cellular response to cell-matrix adhesion
• cellular response to epidermal growth factor stimulus
• cellular response to glucocorticoid stimulus
• cellular response to insulin stimulus
• cellular response to lipopolysaccharide
• central nervous system development
• common myeloid progenitor cell proliferation
• glutathione derivative biosynthetic process
• glutathione metabolic process
• hepoxilin biosynthetic process
• linoleic acid metabolic process
• negative regulation of acute inflammatory response
• negative regulation of apoptotic process
• negative regulation of canonical NF-kappaB signal transduction
• negative regulation of ERK1 and ERK2 cascade
• negative regulation of extrinsic apoptotic signaling pathway
• negative regulation of ferroptosis
• negative regulation of fibroblast proliferation
• negative regulation of interleukin-1 beta production
• negative regulation of JNK cascade
• negative regulation of leukocyte proliferation
• negative regulation of MAPK cascade
• negative regulation of monocyte chemotactic protein-1 production
• negative regulation of smooth muscle cell chemotaxis
• negative regulation of stress-activated MAPK cascade
• negative regulation of transcription by RNA polymerase II
• negative regulation of tumor necrosis factor production
• negative regulation of tumor necrosis factor-mediated signaling pathway
• negative regulation of vascular associated smooth muscle cell proliferation
• oligodendrocyte development
• positive regulation of superoxide anion generation
• prostaglandin metabolic process
• regulation of ERK1 and ERK2 cascade
• regulation of stress-activated MAPK cascade
• response to amino acid
• response to estradiol
• response to ethanol
• response to L-ascorbic acid
• response to reactive oxygen species
• xenobiotic metabolic process
• nitric oxide storage

Molecular functions

• fatty acid binding
• glutathione peroxidase activity
• glutathione transferase activity
• JUN kinase binding
• nitric oxide binding
• protein serine/threonine kinase inhibitor activity
• toxic substance binding
• dinitrosyl-iron complex binding
• S-nitrosoglutathione binding

Cellular components

• cytoplasm
• cytosol
• extracellular exosome
• extracellular region
• extracellular space
• ficolin-1-rich granule lumen
• mitochondrion
• nucleus
• secretory granule lumen
• TRAF2-GSTP1 complex
• vesicle

Protein domainsUniProt · Pfam · InterPro

• Glutathione S-transferase, N-terminal
• Glutathione S-transferase, C-terminal
• Glutathione S-transferase, C-terminal-like
• Thioredoxin-like superfamily
• Glutathione S-transferase, C-terminal domain superfamily
• Glutathione transferase family
• Glutathione S-transferase superfamily
• Glutathione S-transferase, N-terminal domain
• Glutathione S-transferase, C-terminal domain
• Glutathione S-transferase, Pi class

KeywordsUniProt

• Acetylation
• Cytoplasm
• Isopeptide bond
• Lipid metabolism
• Mitochondrion
• Nucleus
• Phosphoprotein
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of GSTP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDK5
• PRDX6
• FBXO8
• TRAF2