Seroatlas · Human Serome Atlas

CABLES2

CDK5 and ABL1 enzyme substrate 2

Also known as: C20orf150, CABL2_HUMAN, dJ908M14.2, ik3-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BTV7
Gene: CABLES2
Ensembl: ENSG00000149679
Chromosome: 20
Canonical length: 478 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Predicted to be involved in cell division and regulation of cell cycle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>Q9BTV7|CABLES2
     1  MAAAAAGGAP GPAPGPAGPP PPAAPTSAAR APPQALRRRG DSRRRQAALF FLNNISLDGR
    61  PPSLGPGGEK PPPPPAEARE PPAPPPPEPP TGLPARTPAP QGLLSPTQVP TGLGLDGQRQ
   121  RKRVTSQRCS LEFLEDAVGC APAQRTKHTS GSPRHKGLKK THFIKNMRQY DTRNSRIVLI
   181  CAKRSLCAAF SVLPYGEGLR ISDLRVDSQK QRHPSGGVSV SSEMVFELEG VELGADGKVV
   241  SYAKFLYPTN ALVTHKSDSH GLLPTPRPSV PRTLPGSRHK PAPTKSAPAS TELGSDVGDT
   301  LEYNPNLLDD PQWPCGKHKR VLIFASYMTT VIEYVKPSDL KKDMNETFRE KFPHVKLTLS
   361  KIRSLKREMR SLSEECSLEP VTVAMAYVYF EKLVLQGKLS KQNRKLCAGA CVLLAAKISS
   421  DLRKSGVTQL IDKLEERFRF NRRDLIGFEF TVLVALELAL YLPENQVLPH YRRLTQQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CABLES2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
cerebellum: 14 nTPM
heart muscle: 10 nTPM
cerebral cortex: 8.3 nTPM
bone marrow: 7.6 nTPM
pituitary gland: 5.7 nTPM

Single-cell type

late primary spermatocytes: 59 nCPM
late spermatids: 39 nCPM
early spermatids: 33 nCPM
neutrophils: 18 nCPM
early primary spermatocytes: 17 nCPM
sertoli cells: 14 nCPM

Immune cell

T-reg: 1.3 nTPM
gdT-cell: 0.7 nTPM
memory B-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
memory CD4 T-cell: 0.4 nTPM

Brain region

cerebellum: 22 nTPM
cerebral cortex: 15 nTPM
pons: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 14 nTPM
hypothalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.89
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CABLES2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CABLES2 as an antibody target. Whether an autoantibody or antibody against CABLES2 could matter depends on whether native CABLES2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CABLES2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CABLES2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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