Seroatlas · Human Serome Atlas

CCNI

Cyclin-I

Also known as: CCNI_HUMAN, CCNI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14094
Gene: CCNI
Ensembl: ENSG00000118816
Chromosome: 4
Canonical length: 377 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Golgi apparatus

OverviewNCBI Gene

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q14094|CCNI
     1  MKFPGPLENQ RLSFLLEKAI TREAQMWKVN VRKMPSNQNV SPSQRDEVIQ WLAKLKYQFN
    61  LYPETFALAS SLLDRFLATV KAHPKYLSCI AISCFFLAAK TVEEDERIPV LKVLARDSFC
   121  GCSSSEILRM ERIILDKLNW DLHTATPLDF LHIFHAIAVS TRPQLLFSLP KLSPSQHLAV
   181  LTKQLLHCMA CNQLLQFRGS MLALAMVSLE MEKLIPDWLS LTIELLQKAQ MDSSQLIHCR
   241  ELVAHHLSTL QSSLPLNSVY VYRPLKHTLV TCDKGVFRLH PSSVPGPDFS KDNSKPEVPV
   301  RGTAAFYHHL PAASGCKQTS TKRKVEEMEV DDFYDGIKRL YNEDNVSENV GSVCGTDLSR
   361  QEGHASPCPP LQPVSVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 297 nTPM

Expression across tissuesHPA

Tissue

ovary: 297 nTPM
cerebellum: 286 nTPM
blood vessel: 285 nTPM
thyroid gland: 256 nTPM
epididymis: 235 nTPM
cerebral cortex: 227 nTPM

Single-cell type

esophageal apical cells: 2,300 nCPM
oocytes: 1,124 nCPM
undifferentiated spermatogonia: 1,043 nCPM
parietal cells: 921 nCPM
decidual stromal cells: 911 nCPM
kupffer cells: 884 nCPM

Immune cell

eosinophil: 238 nTPM
naive CD4 T-cell: 166 nTPM
basophil: 162 nTPM
memory CD4 T-cell: 158 nTPM
naive B-cell: 154 nTPM
T-reg: 150 nTPM

Brain region

cerebellum: 485 nTPM
white matter: 417 nTPM
cerebral cortex: 406 nTPM
midbrain: 360 nTPM
thalamus: 359 nTPM
basal ganglia: 353 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCNI.

Disease | ImmuneIEDB

Conditions an epitope on CCNI was assayed in.

skin melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.83
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNI in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CDK5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNI as an antibody target. Whether an autoantibody or antibody against CCNI could matter depends on whether native CCNI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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