Seroatlas · Human Serome Atlas

NR1H2

Oxysterols receptor LXR-beta

Also known as: LXR-b, LXRb, NER, NER-I, NR1H2_HUMAN, RIP15, UNR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P55055
Gene: NR1H2
Ensembl: ENSG00000131408
Chromosome: 19
Canonical length: 460 aa
Protein class: Cancer-related genes, Nuclear receptors, Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

Canonical amino-acid sequenceUniProt

460 residues, UniProt reviewed canonical sequence.

>P55055|NR1H2
     1  MSSPTTSSLD TPLPGNGPPQ PGAPSSSPTV KEEGPEPWPG GPDPDVPGTD EASSACSTDW
    61  VIPDPEEEPE RKRKKGPAPK MLGHELCRVC GDKASGFHYN VLSCEGCKGF FRRSVVRGGA
   121  RRYACRGGGT CQMDAFMRRK CQQCRLRKCK EAGMREQCVL SEEQIRKKKI RKQQQESQSQ
   181  SQSPVGPQGS SSSASGPGAS PGGSEAGSQG SGEGEGVQLT AAQELMIQQL VAAQLQCNKR
   241  SFSDQPKVTP WPLGADPQSR DARQQRFAHF TELAIISVQE IVDFAKQVPG FLQLGREDQI
   301  ALLKASTIEI MLLETARRYN HETECITFLK DFTYSKDDFH RAGLQVEFIN PIFEFSRAMR
   361  RLGLDDAEYA LLIAINIFSA DRPNVQEPGR VEALQQPYVE ALLSYTRIKR PQDQLRFPRM
   421  LMKLVSLRTL SSVHSEQVFA LRLQDKKLPP LLSEIWDVHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NR1H2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 141 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 141 nTPM
bone marrow: 135 nTPM
blood vessel: 124 nTPM
heart muscle: 91 nTPM
colon: 83 nTPM
urinary bladder: 83 nTPM

Single-cell type

syncytiotrophoblasts: 191 nCPM
esophageal apical cells: 136 nCPM
platelets: 109 nCPM
megakaryocytes: 105 nCPM
endometrial ciliated cells: 97 nCPM
enterocytes: 95 nCPM

Immune cell

eosinophil: 233 nTPM
neutrophil: 196 nTPM
basophil: 160 nTPM
non-classical monocyte: 147 nTPM
total PBMC: 129 nTPM
intermediate monocyte: 126 nTPM

Brain region

medulla oblongata: 90 nTPM
thalamus: 76 nTPM
pons: 74 nTPM
midbrain: 74 nTPM
cerebral cortex: 72 nTPM
white matter: 71 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.38
gnomAD missense Z: 0.89
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NR1H2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NR1H2 as an antibody target. Whether an autoantibody or antibody against NR1H2 could matter depends on whether native NR1H2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NR1H2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NR1H2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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