Seroatlas · Human Serome Atlas

ZNF326

DBIRD complex subunit ZNF326

Also known as: FLJ20403, ZAN75, Zfp326, ZIRD, ZN326_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q5BKZ1
Gene
ZNF326
Ensembl
ENSG00000162664
Chromosome
1
Canonical length
582 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Vesicles

OverviewNCBI Gene

Enables RNA polymerase II complex binding activity. Involved in regulation of DNA-templated transcription elongation and regulation of RNA splicing. Located in nucleoplasm. Part of DBIRD complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

582 residues, UniProt reviewed canonical sequence.

>Q5BKZ1|ZNF326
     1  MDFEDDYTHS ACRNTYQGFN GMDRDYGPGS YGGMDRDYGH GSYGGQRSMD SYLNQSYGMD
    61  NHSGGGGGSR FGPYESYDSR SSLGGRDLYR SGYGFNEPEQ SRFGGSYGGR FESSYRNSLD
   121  SFGGRNQGGS SWEAPYSRSK LRPGFMEDRG RENYSSYSSF SSPHMKPAPV GSRGRGTPAY
   181  PESTFGSRNY DAFGGPSTGR GRGRGHMGDF GSIHRPGIVV DYQNKSTNVT VAAARGIKRK
   241  MMQPFNKPSG TFIKKPKLAK PMEKISLSKS PTKTDPKNEE EEKRRIEARR EKQRRRREKN
   301  SEKYGDGYRM AFTCSFCKFR TFEEKDIELH LESSSHQETL DHIQKQTKFD KVVMEFLHEC
   361  MVNKFKKTSI RKQQTNNQTE VVKIIEKDVM EGVTVDDHMM KVETVHCSAC SVYIPALHSS
   421  VQQHLKSPDH IKGKQAYKEQ IKRESVLTAT SILNNPIVKA RYERFVKGEN PFEIQDHSQD
   481  QQIEGDEEDE EKIDEPIEEE EDEDEEEEAE EVGEVEEVEE VEEVREGGIE GEGNIQGVGE
   541  GGEVGVVGEV EGVGEVEEVE ELEEETAKEE PADFPVEQPE EN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF326 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
49 nTPM

Expression across tissuesHPA

Tissue

  • retina: 49 nTPM
  • bone marrow: 20 nTPM
  • spinal cord: 10 nTPM
  • pancreas: 9.1 nTPM
  • small intestine: 8.4 nTPM
  • cerebellum: 8.3 nTPM

Single-cell type

  • rod photoreceptor cells: 552 nCPM
  • cone photoreceptor cells: 389 nCPM
  • ocular epithelial cells: 248 nCPM
  • esophageal apical cells: 214 nCPM
  • sertoli cells: 172 nCPM
  • retinal bipolar cells: 165 nCPM

Immune cell

  • NK-cell: 2 nTPM
  • plasmacytoid DC: 1.7 nTPM
  • naive B-cell: 1.5 nTPM
  • non-classical monocyte: 1.5 nTPM
  • intermediate monocyte: 1.4 nTPM
  • eosinophil: 1.2 nTPM

Brain region

  • white matter: 25 nTPM
  • cerebellum: 23 nTPM
  • medulla oblongata: 20 nTPM
  • hippocampal formation: 19 nTPM
  • basal ganglia: 19 nTPM
  • spinal cord: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.9
gnomAD missense Z
1.58
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZNF326 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF326 as an antibody target. Whether an autoantibody or antibody against ZNF326 could matter depends on whether native ZNF326 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF326 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF326 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ZNF326. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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