Seroatlas · Human Serome Atlas

GARIN2

Golgi-associated RAB2 interactor protein 2

Also known as: C14orf54, FAM71D, GAR2_HUMAN, GARI-L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N9W8
Gene: GARIN2
Ensembl: ENSG00000172717
Chromosome: 14
Canonical length: 422 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to act upstream of or within cell morphogenesis; penetration of zona pellucida; and spermatid development. Predicted to be located in sperm midpiece. Predicted to be active in sperm head. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

422 residues, UniProt reviewed canonical sequence.

>Q8N9W8|GARIN2
     1  MKKNTSKTTM RINKQDALCT PHSHDPRDLQ NMLDGGEYAP FVSPPMLESN FIQVNRRGES
    61  IYLHNRANWV TVGICFSSST HKIPNVMLLA HLTPGAQKDT ETLFKSLLTS PPAEKLVLTR
   121  FLPLQFVTLS VHDAENMSLK VKLVSGRAYY LQLCTSAYKQ DTLFSQWVAL ISLLNQEKAK
   181  VSKVSEVSSL SGITNSTDIT GSMDVTDVTT FTAILTPYMY AGTGPEHVRD SIDFPEFTDI
   241  TDITDVTDLP ENEVPEVPDV RIVTEVIEVR EATEVTDSSD ITNCSGVTVV FENNDLIRAK
   301  QEEKEKLKNI LKPGCLQDTK SKSELKESSK HVTISNITLT FEGKRYFQTT LTPVESEANT
   361  SKEMKDKTSE EKMPDFQSTA LKAEESRSLR TESNTSVLSP HIKSPSNFLK LVPHLSAPFS
   421  RE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GARIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

testis: 22 nTPM
retina: 0.8 nTPM
skin: 0.3 nTPM
duodenum: 0.2 nTPM
epididymis: 0.2 nTPM
heart muscle: 0.2 nTPM

Single-cell type

late spermatids: 432 nCPM
early spermatids: 312 nCPM
late primary spermatocytes: 53 nCPM
cardiomyocytes: 17 nCPM
rod photoreceptor cells: 9.9 nCPM
epicardial cells: 9.1 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
gdT-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebellum: 4.6 nTPM
cerebral cortex: 3.4 nTPM
hypothalamus: 3.4 nTPM
white matter: 3.4 nTPM
basal ganglia: 2.6 nTPM
pons: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

sperm midpiece

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GARIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CALM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GARIN2 as an antibody target. Whether an autoantibody or antibody against GARIN2 could matter depends on whether native GARIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GARIN2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GARIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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