Calmodulin/Myosin light chain/Troponin C-like
IPR050230
Definition
The protein family is involved in calcium-mediated regulation of muscle contraction and cellular processes. Members of the family serve as regulatory proteins in striated muscle contraction, with troponin components (Tn-I, Tn-T, Tn-C) that respond to calcium binding by modulating actomyosin ATPase activity PMID:33755597. Other members, such as calmodulins and calglandulins, mediate the control of various enzymes, ion channels, and proteins through calcium signalling [[cite:PMID:12758151], [cite:PMID:28890335], [cite:PMID:31454269], [cite:PMID:35568036]]. Some light chains of myosin are essential for ATPase activity, while others are regulatory, influencing myosin's interaction with actin PMID:30215711. Additionally, the family includes proteins potentially involved in secretion of toxins from venom glands and in cellular control mechanisms PMID:12758151. The family showcases a diversity of calcium-binding proteins with roles in muscle function, enzyme regulation, and cellular responses to calcium.
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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