Seroatlas · Human Serome Atlas

HINT3

Adenosine 5'-monophosphoramidase HINT3

Also known as: FLJ33126, HINT3_HUMAN, HINT4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NQE9
Gene: HINT3
Ensembl: ENSG00000111911
Chromosome: 6
Canonical length: 182 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Mitochondria,Cytosol

OverviewNCBI Gene

Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9NQE9|HINT3
     1  MAEEQVNRSA GLAPDCEASA TAETTVSSVG TCEAAGKSPE PKDYDSTCVF CRIAGRQDPG
    61  TELLHCENED LICFKDIKPA ATHHYLVVPK KHIGNCRTLR KDQVELVENM VTVGKTILER
   121  NNFTDFTNVR MGFHMPPFCS ISHLHLHVLA PVDQLGFLSK LVYRVNSYWF ITADHLIEKL
   181  RT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HINT3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 106 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 106 nTPM
tongue: 79 nTPM
spinal cord: 56 nTPM
midbrain: 38 nTPM
hippocampal formation: 34 nTPM
amygdala: 34 nTPM

Single-cell type

early spermatids: 396 nCPM
late primary spermatocytes: 260 nCPM
early primary spermatocytes: 106 nCPM
esophageal apical cells: 95 nCPM
late spermatids: 77 nCPM
parietal cells: 71 nCPM

Immune cell

basophil: 13 nTPM
neutrophil: 11 nTPM
classical monocyte: 9.3 nTPM
eosinophil: 8.9 nTPM
non-classical monocyte: 8.6 nTPM
myeloid DC: 7.7 nTPM

Brain region

white matter: 50 nTPM
spinal cord: 48 nTPM
medulla oblongata: 43 nTPM
basal ganglia: 41 nTPM
thalamus: 39 nTPM
pons: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HINT3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CALM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HINT3 as an antibody target. Whether an autoantibody or antibody against HINT3 could matter depends on whether native HINT3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HINT3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HINT3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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