Seroatlas · Human Serome Atlas

CEP97

Centrosomal protein of 97 kDa

Also known as: CEP97_HUMAN, FLJ23047, LRRIQ2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IW35
Gene: CEP97
Ensembl: ENSG00000182504
Chromosome: 3
Canonical length: 865 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Centrosome,Basal body,Cytosol

OverviewNCBI Gene

Predicted to enable U2 snRNA binding activity and calmodulin binding activity. Involved in negative regulation of cilium assembly and regulation of mitotic spindle assembly. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

865 residues, UniProt reviewed canonical sequence.

>Q8IW35|CEP97
     1  MAVARVDAAL PPGEGSVVNW SGQGLQKLGP NLPCEADIHT LILDKNQIIK LENLEKCKRL
    61  IQLSVANNRL VRMMGVAKLT LLRVLNLPHN SIGCVEGLKE LVHLEWLNLA GNNLKAMEQI
   121  NSCTALQHLD LSDNNISQIG DLSKLVSLKT LLLHGNIITS LRMAPAYLPR SLAILSLAEN
   181  EIRDLNEISF LASLTELEQL SIMNNPCVMA TPSIPGFDYR PYIVSWCLNL RVLDGYVISQ
   241  KESLKAEWLY SQGKGRAYRP GQHIQLVQYL ATVCPLTSTL GLQTAEDAKL EKILSKQRFH
   301  QRQLMNQSQN EELSPLVPVE TRASLIPEHS SPVQDCQISQ ESEPVIQVNS WVGINSNDDQ
   361  LFAVKNNFPA SVHTTRYSRN DLHLEDIQTD EDKLNCSLLS SESTFMPVAS GLSPLSPTVE
   421  LRLQGINLGL EDDGVADESV KGLESQVLDK EEEQPLWAAN ENSVQMMRSE INTEVNEKAG
   481  LLPCPEPTII SAILKDDNHS LTFFPESTEQ KQSDIKKPEN TQPENKETIS QATSEKLPMI
   541  LTQRSVALGQ DKVALQKLND AATKLQACWR GFYARNYNPQ AKDVRYEIRL RRMQEHIVCL
   601  TDEIRRLRKE RDEERIKKFV QEEAFRFLWN QVRSLQVWQQ TVDQRLSSWH TDVPPISSTL
   661  VPSKHPLFTQ SQESSCDQNA DWFIASDVAP QEKSLPEFPD SGFHSSLTEQ VHSLQHSLDF
   721  EKSSTEGSES SIMGNSIDTV RYGKESDLGD VSEEHGEWNK ESSNNEQDNS LLEQYLTSVQ
   781  QLEDADERTN FDTETRDSKL HIACFPVQLD TLSDGASVDE SHGISPPLQG EISQTQENSK
   841  LNAEVQGQQP ECDSTFQLLH VGVTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEP97 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 5.8 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.8 nTPM
spinal cord: 5.6 nTPM
hippocampal formation: 5.4 nTPM
cerebral cortex: 5.2 nTPM
parathyroid gland: 5.2 nTPM
testis: 5.2 nTPM

Single-cell type

oligodendrocytes: 123 nCPM
respiratory ciliated cells: 92 nCPM
ependymal cells: 85 nCPM
oligodendrocyte progenitor cells: 76 nCPM
fallopian tube ciliated cells: 72 nCPM
adrenal medulla cells: 64 nCPM

Immune cell

basophil: 1.7 nTPM
memory B-cell: 0.7 nTPM
eosinophil: 0.6 nTPM
T-reg: 0.6 nTPM
gdT-cell: 0.5 nTPM
MAIT T-cell: 0.5 nTPM

Brain region

white matter: 11 nTPM
cerebellum: 6.8 nTPM
pons: 6.4 nTPM
hypothalamus: 6.2 nTPM
spinal cord: 6 nTPM
basal ganglia: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CEP97.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 359 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.37
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calmodulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CEP97 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEP97 as an antibody target. Whether an autoantibody or antibody against CEP97 could matter depends on whether native CEP97 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEP97 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEP97 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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