Seroatlas · Human Serome Atlas

CCP110

Centriolar coiled-coil protein of 110 kDa

Also known as: CP110, CP110_HUMAN, KIAA0419

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O43303
Gene: CCP110
Ensembl: ENSG00000103540
Chromosome: 16
Canonical length: 1012 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Centriolar satellite

OverviewNCBI Gene

Involved in centriole replication; negative regulation of cilium assembly; and regulation of cytokinesis. Located in centriole and centrosome. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1012 residues, UniProt reviewed canonical sequence.

>O43303|CCP110
     1  MEEYEKFCEK SLARIQEASL STESFLPAQS ESISLIRFHG VAILSPLLNI EKRKEMQQEK
    61  QKALDVEARK QVNRKKALLT RVQEILDNVQ VRKAPNASDF DQWEMETVYS NSEVRNLNVP
   121  ATFPNSFPSH TEHSTAAKLD KIAGILPLDN EDQCKTDGID LARDSEGFNS PKQCDSSNIS
   181  HVENEAFPKT SSATPQETLI SDGPFSVNEQ QDLPLLAEVI PDPYVMSLQN LMKKSKEYIE
   241  REQSRRSLRG SINRIVNESH LDKEHDAVEV ADCVKEKGQL TGKHCVSVIP DKPSLNKSNV
   301  LLQGASTQAS SMSMPVLASF SKVDIPIRTG HPTVLESNSD FKVIPTFVTE NNVIKSLTGS
   361  YAKLPSPEPS MSPKMHRRRS RTSSACHILI NNPINACELS PKGKEQAMDL IIQDTDENTN
   421  VPEIMPKLPT DLAGVCSSKV YVGKNTSEVK EDVVLGKSNQ VCQSSGNHLE NKVTHGLVTV
   481  EGQLTSDERG AHIMNSTCAA MPKLHEPYAS SQCIASPNFG TVSGLKPASM LEKNCSLQTE
   541  LNKSYDVKNP SPLLMQNQNT RQQMDTPMVS CGNEQFLDNS FEKVKRRLDL DIDGLQKENC
   601  PYVITSGITE QERQHLPEKR YPKGSGFVNK NKMLGTSSKE SEELLKSKML AFEEMRKRLE
   661  EQHAQQLSLL IAEQEREQER LQKEIEEQEK MLKEKKAMTA EASELDINNA VELEWRKISD
   721  SSLLETMLSQ ADSLHTSNSN SSGFTNSAMQ YSFVSANEAP FYLWGSSTSG LTKLSVTRPF
   781  GRAKTRWSQV FSLEIQAKFN KITAVAKGFL TRRLMQTDKL KQLRQTVKDT MEFIRSFQSE
   841  APLKRGIVSA QDASLQERVL AQLRAALYGI HDIFFVMDAA ERMSILHHDR EVRKEKMLRQ
   901  MDKMKSPRVA LSAATQKSLD RKKYMKAAEM GMPNKKFLVK QNPSETRVLQ PNQGQNAPVH
   961  RLLSRQGTPK TSVKGVVQNR QKPSQSRVPN RVPVSGVYAG KIQRKRPNVA TI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCP110 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

testis: 33 nTPM
hippocampal formation: 24 nTPM
midbrain: 24 nTPM
basal ganglia: 20 nTPM
amygdala: 19 nTPM
spinal cord: 18 nTPM

Single-cell type

oligodendrocytes: 290 nCPM
early primary spermatocytes: 182 nCPM
respiratory ciliated cells: 171 nCPM
fallopian tube ciliated cells: 129 nCPM
epididymal efferent duct ciliated cells: 112 nCPM
endometrial ciliated cells: 109 nCPM

Immune cell

basophil: 15 nTPM
neutrophil: 5.5 nTPM
eosinophil: 5.3 nTPM
non-classical monocyte: 4.3 nTPM
naive CD4 T-cell: 3.9 nTPM
gdT-cell: 3.8 nTPM

Brain region

white matter: 99 nTPM
basal ganglia: 84 nTPM
thalamus: 65 nTPM
midbrain: 64 nTPM
medulla oblongata: 58 nTPM
cerebral cortex: 58 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCP110.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 148 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.01
gnomAD missense Z: 1.28
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centriolar coiled-coil protein of 110kDa
Calcium-dependent calmodulin binding

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCP110 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCP110 as an antibody target. Whether an autoantibody or antibody against CCP110 could matter depends on whether native CCP110 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCP110 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCP110 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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