Seroatlas · Human Serome Atlas

WIPI2

WD repeat domain phosphoinositide-interacting protein 2

Also known as: ATG18B, ATG21, CGI-50, DKFZP434J154, DKFZp686P02188, FLJ12979, FLJ14217, FLJ42984, WIPI2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y4P8
Gene
WIPI2
Ensembl
ENSG00000157954
Chromosome
7
Canonical length
454 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

454 residues, UniProt reviewed canonical sequence.

>Q9Y4P8|WIPI2
     1  MNLASQSGEA GAGQLLFANF NQDNTEVKGA SRAAGLGRRA VVWSLAVGSK SGYKFFSLSS
    61  VDKLEQIYEC TDTEDVCIVE RLFSSSLVAI VSLKAPRKLK VCHFKKGTEI CNYSYSNTIL
   121  AVKLNRQRLI VCLEESLYIH NIRDMKVLHT IRETPPNPAG LCALSINNDN CYLAYPGSAT
   181  IGEVQVFDTI NLRAANMIPA HDSPLAALAF DASGTKLATA SEKGTVIRVF SIPEGQKLFE
   241  FRRGVKRCVS ICSLAFSMDG MFLSASSNTE TVHIFKLETV KEKPPEEPTT WTGYFGKVLM
   301  ASTSYLPSQV TEMFNQGRAF ATVRLPFCGH KNICSLATIQ KIPRLLVGAA DGYLYMYNLD
   361  PQEGGECALM KQHRLDGSLE TTNEILDSAS HDCPLVTQTY GAAAGKGTYV PSSPTRLAYT
   421  DDLGAVGGAC LEDEASALRL DEDSEHPPMI LRTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIPI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • testis: 51 nTPM
  • choroid plexus: 51 nTPM
  • skin: 45 nTPM
  • bone marrow: 44 nTPM
  • cerebral cortex: 44 nTPM
  • tongue: 42 nTPM

Single-cell type

  • late spermatids: 302 nCPM
  • late primary spermatocytes: 286 nCPM
  • esophageal apical cells: 255 nCPM
  • early primary spermatocytes: 205 nCPM
  • early spermatids: 188 nCPM
  • syncytiotrophoblasts: 181 nCPM

Immune cell

  • eosinophil: 14 nTPM
  • neutrophil: 9.1 nTPM
  • T-reg: 9 nTPM
  • memory CD8 T-cell: 8 nTPM
  • naive CD4 T-cell: 7.5 nTPM
  • plasmacytoid DC: 6.4 nTPM

Brain region

  • cerebral cortex: 64 nTPM
  • basal ganglia: 59 nTPM
  • midbrain: 59 nTPM
  • white matter: 58 nTPM
  • pons: 57 nTPM
  • hippocampal formation: 56 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WIPI2.

Disease | AllUniProt

Conditions WIPI2 is implicated in, by any mechanism.

  • Intellectual developmental disorder with short stature and variable skeletal anomalies (IDDSSA) MIM:618453

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 109 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Intellectual developmental disorder with short stature and variable skeletal anomalies

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.62
gnomAD pLI
0.01
gnomAD missense Z
1.66
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIPI2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIPI2 as an antibody target. Whether an autoantibody or antibody against WIPI2 could matter depends on whether native WIPI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIPI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIPI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WIPI2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...