Seroatlas · Human Serome Atlas

TMEM59

Transmembrane protein 59

Also known as: C1orf8, HSPC001, TMM59_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXS4
Gene: TMEM59
Ensembl: ENSG00000116209
Chromosome: 1
Canonical length: 323 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>Q9BXS4|TMEM59
     1  MAAPKGSLWV RTQLGLPPLL LLTMALAGGS GTASAEAFDS VLGDTASCHR ACQLTYPLHT
    61  YPKEEELYAC QRGCRLFSIC QFVDDGIDLN RTKLECESAC TEAYSQSDEQ YACHLGCQNQ
   121  LPFAELRQEQ LMSLMPKMHL LFPLTLVRSF WSDMMDSAQS FITSSWTFYL QADDGKIVIF
   181  QSKPEIQYAP HLEQEPTNLR ESSLSKMSYL QMRNSQAHRN FLEDGESDGF LRCLSLNSGW
   241  ILTTTLVLSV MVLLWICCAT VATAVEQYVP SEKLSIYGDL EFMNEQKLNR YPASSLVVVR
   301  SKTEDHEEAG PLPTKVNLAH SEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TMEM59 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1,031 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 1,031 nTPM
pancreas: 553 nTPM
salivary gland: 518 nTPM
parathyroid gland: 500 nTPM
liver: 472 nTPM
colon: 457 nTPM

Single-cell type

esophageal apical cells: 2,658 nCPM
fallopian tube ciliated cells: 1,238 nCPM
parietal cells: 1,073 nCPM
gastric chief cells: 976 nCPM
enterocytes: 967 nCPM
plasma cells: 864 nCPM

Immune cell

neutrophil: 1,202 nTPM
basophil: 1,186 nTPM
total PBMC: 1,154 nTPM
eosinophil: 834 nTPM
classical monocyte: 656 nTPM
non-classical monocyte: 598 nTPM

Brain region

choroid plexus: 566 nTPM
white matter: 361 nTPM
medulla oblongata: 275 nTPM
cerebellum: 271 nTPM
spinal cord: 261 nTPM
basal ganglia: 223 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

endopeptidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TMEM59 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TMEM59 as an antibody target. Whether an autoantibody or antibody against TMEM59 could matter depends on whether native TMEM59 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TMEM59 is annotated at the cell surface, where native TMEM59 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TMEM59 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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