Seroatlas · Human Serome Atlas

WIPI1

WD repeat domain phosphoinositide-interacting protein 1

Also known as: ATG18, ATG18A, FLJ10055, WIPI1_HUMAN, WIPI49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5MNZ9
Gene: WIPI1
Ensembl: ENSG00000070540
Chromosome: 17
Canonical length: 446 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

This gene encodes a WD40 repeat protein. Members of the WD40 repeat family are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q5MNZ9|WIPI1
     1  MEAEAADAPP GGVESALSCF SFNQDCTSLA TGTKAGYKLF SLSSVEQLDQ VHGSNEIPDV
    61  YIVERLFSSS LVVVVSHTKP RQMNVYHFKK GTEICNYSYS SNILSIRLNR QRLLVCLEES
   121  IYIHNIKDMK LLKTLLDIPA NPTGLCALSI NHSNSYLAYP GSLTSGEIVL YDGNSLKTVC
   181  TIAAHEGTLA AITFNASGSK LASASEKGTV IRVFSVPDGQ KLYEFRRGMK RYVTISSLVF
   241  SMDSQFLCAS SNTETVHIFK LEQVTNSRPE EPSTWSGYMG KMFMAATNYL PTQVSDMMHQ
   301  DRAFATARLN FSGQRNICTL STIQKLPRLL VASSSGHLYM YNLDPQDGGE CVLIKTHSLL
   361  GSGTTEENKE NDLRPSLPQS YAATVARPSA SSASTVPGYS EDGGALRGEV IPEHEFATGP
   421  VCLDDENEFP PIILCRGNQK GKTKQS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WIPI1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 119 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 119 nTPM
tongue: 91 nTPM
heart muscle: 74 nTPM
placenta: 59 nTPM
salivary gland: 55 nTPM
choroid plexus: 51 nTPM

Single-cell type

extravillous trophoblasts: 295 nCPM
syncytiotrophoblasts: 224 nCPM
platelets: 212 nCPM
respiratory secretory cells: 204 nCPM
respiratory deuterosomal cells: 139 nCPM
breast lactating cells: 133 nCPM

Immune cell

eosinophil: 224 nTPM
basophil: 115 nTPM
neutrophil: 39 nTPM
non-classical monocyte: 25 nTPM
intermediate monocyte: 23 nTPM
classical monocyte: 19 nTPM

Brain region

choroid plexus: 25 nTPM
thalamus: 18 nTPM
hypothalamus: 12 nTPM
pons: 11 nTPM
cerebellum: 11 nTPM
medulla oblongata: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.32
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WIPI1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WIPI1 as an antibody target. Whether an autoantibody or antibody against WIPI1 could matter depends on whether native WIPI1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WIPI1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WIPI1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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