Seroatlas · Human Serome Atlas

CTNNA1

Catenin alpha-1

Also known as: CAP102, CTNA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35221
Gene
CTNNA1
Ensembl
ENSG00000044115
Chromosome
5
Canonical length
906 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Plasma membrane,Cell Junctions,Connecting piece,Mid piece,Principal piece
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]

Canonical amino-acid sequenceUniProt

906 residues, UniProt reviewed canonical sequence.

>P35221|CTNNA1
     1  MTAVHAGNIN FKWDPKSLEI RTLAVERLLE PLVTQVTTLV NTNSKGPSNK KRGRSKKAHV
    61  LAASVEQATE NFLEKGDKIA KESQFLKEEL VAAVEDVRKQ GDLMKAAAGE FADDPCSSVK
   121  RGNMVRAARA LLSAVTRLLI LADMADVYKL LVQLKVVEDG ILKLRNAGNE QDLGIQYKAL
   181  KPEVDKLNIM AAKRQQELKD VGHRDQMAAA RGILQKNVPI LYTASQACLQ HPDVAAYKAN
   241  RDLIYKQLQQ AVTGISNAAQ ATASDDASQH QGGGGGELAY ALNNFDKQII VDPLSFSEER
   301  FRPSLEERLE SIISGAALMA DSSCTRDDRR ERIVAECNAV RQALQDLLSE YMGNAGRKER
   361  SDALNSAIDK MTKKTRDLRR QLRKAVMDHV SDSFLETNVP LLVLIEAAKN GNEKEVKEYA
   421  QVFREHANKL IEVANLACSI SNNEEGVKLV RMSASQLEAL CPQVINAALA LAAKPQSKLA
   481  QENMDLFKEQ WEKQVRVLTD AVDDITSIDD FLAVSENHIL EDVNKCVIAL QEKDVDGLDR
   541  TAGAIRGRAA RVIHVVTSEM DNYEPGVYTE KVLEATKLLS NTVMPRFTEQ VEAAVEALSS
   601  DPAQPMDENE FIDASRLVYD GIRDIRKAVL MIRTPEELDD SDFETEDFDV RSRTSVQTED
   661  DQLIAGQSAR AIMAQLPQEQ KAKIAEQVAS FQEEKSKLDA EVSKWDDSGN DIIVLAKQMC
   721  MIMMEMTDFT RGKGPLKNTS DVISAAKKIA EAGSRMDKLG RTIADHCPDS ACKQDLLAYL
   781  QRIALYCHQL NICSKVKAEV QNLGGELVVS GVDSAMSLIQ AAKNLMNAVV QTVKASYVAS
   841  TKYQKSQGMA SLNLPAVSWK MKAPEKKPLV KREKQDETQT KIKRASQKKH VNPVQALSEF
   901  KAMDSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CTNNA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
202 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 202 nTPM
  • heart muscle: 182 nTPM
  • blood vessel: 179 nTPM
  • colon: 146 nTPM
  • adipose tissue: 140 nTPM
  • skin: 136 nTPM

Single-cell type

  • esophageal apical cells: 1,095 nCPM
  • endometrial glandular cells: 930 nCPM
  • endometrial luminal cells: 789 nCPM
  • alveolar cells type 1: 775 nCPM
  • schwann cells: 751 nCPM
  • endometrial ciliated cells: 736 nCPM

Immune cell

  • non-classical monocyte: 47 nTPM
  • intermediate monocyte: 47 nTPM
  • classical monocyte: 38 nTPM
  • myeloid DC: 32 nTPM
  • neutrophil: 21 nTPM
  • total PBMC: 18 nTPM

Brain region

  • white matter: 210 nTPM
  • medulla oblongata: 156 nTPM
  • basal ganglia: 155 nTPM
  • cerebellum: 143 nTPM
  • choroid plexus: 140 nTPM
  • thalamus: 136 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CTNNA1.

Disease | AllUniProt

Conditions CTNNA1 is implicated in, by any mechanism.

  • Macular dystrophy, patterned, 2 (MDPT2) MIM:608970

Disease | GeneticClinVar

240 pathogenic / likely-pathogenic of 3,561 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
3.66
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CTNNA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CTNNA1 as an antibody target. Whether an autoantibody or antibody against CTNNA1 could matter depends on whether native CTNNA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CTNNA1 is annotated at the cell surface, where native CTNNA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CTNNA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CTNNA1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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