EPS8L1

Protein identityUniProt · HPA

UniProt accession

Q8TE68

Gene

EPS8L1

Ensembl

ENSG00000131037

Chromosome

19

Canonical length

723 aa

Protein class

Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

723 residues, UniProt reviewed canonical sequence.

>Q8TE68|EPS8L1
     1  MSTATGPEAA PKPSAKSIYE QRKRYSTVVM ADVSQYPVNH LVTFCLGEDD GVHTVEDASR
    61  KLAVMDSQGR VWAQEMLLRV SPDHVTLLDP ASKEELESYP LGAIVRCDAV MPPGRSRSLL
   121  LLVCQEPERA QPDVHFFQGL RLGAELIRED IQGALHNYRS GRGERRAAAL RATQEELQRD
   181  RSPAAETPPL QRRPSVRAVI STVERGAGRG RPQAKPIPEA EEAQRPEPVG TSSNADSASP
   241  DLGPRGPDLA VLQAEREVDI LNHVFDDVES FVSRLQKSAE AARVLEHRER GRRSRRRAAG
   301  EGLLTLRAKP PSEAEYTDVL QKIKYAFSLL ARLRGNIADP SSPELLHFLF GPLQMIVNTS
   361  GGPEFASSVR RPHLTSDAVA LLRDNVTPRE NELWTSLGDS WTRPGLELSP EEGPPYRPEF
   421  FSGWEPPVTD PQSRAWEDPV EKQLQHERRR RQQSAPQVAV NGHRDLEPES EPQLESETAG
   481  KWVLCNYDFQ ARNSSELSVK QRDVLEVLDD SRKWWKVRDP AGQEGYVPYN ILTPYPGPRL
   541  HHSQSPARSL NSTPPPPPAP APAPPPALAR PRWDRPRWDS CDSLNGLDPS EKEKFSQMLI
   601  VNEELQARLA QGRSGPSRAV PGPRAPEPQL SPGSDASEVR AWLQAKGFSS GTVDALGVLT
   661  GAQLFSLQKE ELRAVSPEEG ARVYSQVTVQ RSLLEDKEKV SELEAVMEKQ KKKVEGEVEM
   721  EVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EPS8L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.4

Highest tissue expression

121 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.03

gnomAD pLI

0

gnomAD missense Z

0.03

DepMap mean gene effect

-0.07

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• positive regulation of ruffle assembly
• regulation of Rho protein signal transduction
• Rho protein signal transduction

Molecular functions

• actin binding
• cadherin binding
• T cell receptor binding

Cellular components

• cytosol
• extracellular exosome
• plasma membrane
• protein-containing complex
• ruffle membrane

Protein domainsUniProt · Pfam · InterPro

• SH3 domain
• PTB/PI domain
• PH-like domain superfamily
• Tensin/EPS8 phosphotyrosine-binding domain
• Sterile alpha motif/pointed domain superfamily
• Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
• Eps8, SH3 domain
• SH3-like domain superfamily
• Epidermal growth factor receptor kinase substrate 8-like
• SAM domain
• EPS8, spectrin-like domain
• SH3 domain
• Phosphotyrosine-binding domain
• SAM domain (Sterile alpha motif)
• EPS8 spectrin-like domain

KeywordsUniProt

• Coiled coil
• Cytoplasm
• Phosphoprotein
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of EPS8L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ABI1
• CD3E