Collagen/C1q domain-containing
IPR050392
Definition
The collagen/C1q domain-containing protein family includes a variety of proteins with roles in structural support, immune response, and regulation of various biological processes. Members of the family are characterized by the presence of a C1q domain, which often mediates calcium-binding and is involved in the formation of organic scaffolds, such as in the inner ear for otoliths or in cartilage for mineralization zones. Some family members are involved in the serum complement system, associating with proenzymes to form the C1 complex, which is activated upon interaction with immune complexes. Others are adipokines, influencing fat metabolism and insulin sensitivity, or serve as carrier proteins for factors involved in coagulation. The family also includes proteins that may regulate vessel assembly, angiogenesis, and tissue remodeling, highlighting a diverse range of functions from structural support to metabolic regulation and immune defense.
22 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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