Seroatlas · Human Serome Atlas

C1QTNF1

Complement C1q tumor necrosis factor-related protein 1

Also known as: C1QT1_HUMAN, CTRP1, FLJ90694, GIP, ZSIG37

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ1
Gene: C1QTNF1
Ensembl: ENSG00000173918
Chromosome: 17
Canonical length: 281 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Nucleoplasm,Cytosol
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables collagen binding activity. Involved in several processes, including negative regulation of platelet aggregation; positive regulation of aldosterone secretion; and positive regulation of cytosolic calcium ion concentration. Located in extracellular space and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

281 residues, UniProt reviewed canonical sequence.

>Q9BXJ1|C1QTNF1
     1  MGSRGQGLLL AYCLLLAFAS GLVLSRVPHV QGEQQEWEGT EELPSPPDHA ERAEEQHEKY
    61  RPSQDQGLPA SRCLRCCDPG TSMYPATAVP QINITILKGE KGDRGDRGLQ GKYGKTGSAG
   121  ARGHTGPKGQ KGSMGAPGER CKSHYAAFSV GRKKPMHSNH YYQTVIFDTE FVNLYDHFNM
   181  FTGKFYCYVP GLYFFSLNVH TWNQKETYLH IMKNEEEVVI LFAQVGDRSI MQSQSLMLEL
   241  REQDQVWVRL YKGERENAIF SEELDTYITF SGYLVKHATE P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 293 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 293 nTPM
heart muscle: 271 nTPM
adipose tissue: 174 nTPM
breast: 132 nTPM
thyroid gland: 95 nTPM
adrenal gland: 64 nTPM

Single-cell type

vascular smooth muscle cells: 272 nCPM
hepatic stellate cells: 155 nCPM
pericytes: 155 nCPM
breast lactating cells: 115 nCPM
epicardial cells: 105 nCPM
syncytiotrophoblasts: 69 nCPM

Immune cell

basophil: 0.3 nTPM
NK-cell: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 91 nTPM
midbrain: 47 nTPM
thalamus: 40 nTPM
medulla oblongata: 33 nTPM
hypothalamus: 33 nTPM
pons: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QTNF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

SGTA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF1 as an antibody target. Whether an autoantibody or antibody against C1QTNF1 could matter depends on whether native C1QTNF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF1 is annotated as secreted, so native C1QTNF1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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