C1QTNF7
Complement C1q tumor necrosis factor-related protein 7
Also known as: C1QT7_HUMAN, CTRP7
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BXJ2
- Gene
- C1QTNF7
- Ensembl
- ENSG00000163145
- Chromosome
- 4
- Canonical length
- 289 aa
- Protein class
- Plasma proteins, Predicted secreted proteins
- Subcellular location
- Vesicles
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Predicted to enable identical protein binding activity. Predicted to be located in extracellular space. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Apr 2025]
Canonical amino-acid sequenceUniProt
289 residues, UniProt reviewed canonical sequence.
>Q9BXJ2|C1QTNF7
1 MFVLLYVTSF AICASGQPRG NQLKGENYSP RYICSIPGLP GPPGPPGANG SPGPHGRIGL
61 PGRDGRDGRK GEKGEKGTAG LRGKTGPLGL AGEKGDQGET GKKGPIGPEG EKGEVGPIGP
121 PGPKGDRGEQ GDPGLPGVCR CGSIVLKSAF SVGITTSYPE ERLPIIFNKV LFNEGEHYNP
181 ATGKFICAFP GIYYFSYDIT LANKHLAIGL VHNGQYRIKT FDANTGNHDV ASGSTVIYLQ
241 PEDEVWLEIF FTDQNGLFSD PGWADSLFSG FLLYVDTDYL DSISEDDELLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1QTNF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 22 nTPM
Expression across tissuesHPA
Tissue
- cervix: 22 nTPM
- blood vessel: 20 nTPM
- ovary: 19 nTPM
- endometrium: 15 nTPM
- gallbladder: 13 nTPM
- smooth muscle: 11 nTPM
Single-cell type
- adipocytes: 269 nCPM
- retinal bipolar cells: 151 nCPM
- fibro-adipogenic progenitors: 104 nCPM
- vascular smooth muscle cells: 68 nCPM
- fibroblasts: 67 nCPM
- peritubular myoid cells: 61 nCPM
Immune cell
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- cerebral cortex: 9 nTPM
- hypothalamus: 7.2 nTPM
- midbrain: 6.8 nTPM
- basal ganglia: 5.7 nTPM
- thalamus: 5.7 nTPM
- cerebellum: 5.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.45
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.73
- DepMap mean gene effect
- 0.21
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1QTNF7 as an antibody target. Whether an autoantibody or antibody against C1QTNF7 could matter depends on whether native C1QTNF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1QTNF7 is annotated as secreted, so native C1QTNF7 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label C1QTNF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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