Seroatlas · Human Serome Atlas

C1QTNF2

Complement C1q tumor necrosis factor-related protein 2

Also known as: C1QT2_HUMAN, CTRP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ5
Gene: C1QTNF2
Ensembl: ENSG00000145861
Chromosome: 5
Canonical length: 285 aa
Protein class: Predicted secreted proteins
Subcellular location: Golgi apparatus,Centrosome
Secretome location: Secreted to blood

OverviewNCBI Gene

Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in regulation of lipid metabolic process. Predicted to act upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Predicted to be located in extracellular space. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q9BXJ5|C1QTNF2
     1  MIPWVLLACA LPCAADPLLG AFARRDFRKG SPQLVCSLPG PQGPPGPPGA PGPSGMMGRM
    61  GFPGKDGQDG HDGDRGDSGE EGPPGRTGNR GKPGPKGKAG AIGRAGPRGP KGVNGTPGKH
   121  GTPGKKGPKG KKGEPGLPGP CSCGSGHTKS AFSVAVTKSY PRERLPIKFD KILMNEGGHY
   181  NASSGKFVCG VPGIYYFTYD ITLANKHLAI GLVHNGQYRI RTFDANTGNH DVASGSTILA
   241  LKQGDEVWLQ IFYSEQNGLF YDPYWTDSLF TGFLIYADQD DPNEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 13 nTPM
heart muscle: 3.9 nTPM
cervix: 3.1 nTPM
endometrium: 3.1 nTPM
fallopian tube: 3 nTPM
adipose tissue: 2.7 nTPM

Single-cell type

vascular smooth muscle cells: 39 nCPM
peritubular myoid cells: 29 nCPM
fibroblasts: 18 nCPM
smooth muscle cells: 16 nCPM
leydig cells: 16 nCPM
fibro-adipogenic progenitors: 16 nCPM

Immune cell

basophil: 1.2 nTPM
neutrophil: 0.2 nTPM
NK-cell: 0.2 nTPM
memory B-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
plasmacytoid DC: 0.1 nTPM

Brain region

thalamus: 6.8 nTPM
midbrain: 4.1 nTPM
cerebellum: 3.9 nTPM
amygdala: 3.4 nTPM
cerebral cortex: 3.3 nTPM
hippocampal formation: 3.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.23
gnomAD pLI: 0
gnomAD missense Z: -0.18
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of lipid metabolic process

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF2 as an antibody target. Whether an autoantibody or antibody against C1QTNF2 could matter depends on whether native C1QTNF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF2 is annotated as secreted, so native C1QTNF2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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