Seroatlas · Human Serome Atlas

C1QB

Complement C1q subcomponent subunit B

Also known as: C1QB_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P02746
Gene: C1QB
Canonical length: 253 aa
Protein class: Human disease related genes, Predicted membrane proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for C1QB in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

253 residues, UniProt reviewed canonical sequence.

>P02746|C1QB
     1  MMMKIPWGSI PVLMLLLLLG LIDISQAQLS CTGPPAIPGI PGIPGTPGPD GQPGTPGIKG
    61  EKGLPGLAGD HGEFGEKGDP GIPGNPGKVG PKGPMGPKGG PGAPGAPGPK GESGDYKATQ
   121  KIAFSATRTI NVPLRRDQTI RFDHVITNMN NNYEPRSGKF TCKVPGLYYF TYHASSRGNL
   181  CVNLMRGRER AQKVVTFCDY AYNTFQVTTG GMVLKLEQGE NVFLQATDKN SLLGMEGANS
   241  IFSGFLLFPD MEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 1,405 nTPM

Expression across tissuesHPA

Tissue

spleen: 1,405 nTPM
lung: 521 nTPM
lymph node: 490 nTPM
choroid plexus: 431 nTPM
adipose tissue: 415 nTPM
smooth muscle: 246 nTPM

Single-cell type

kupffer cells: 7,920 nCPM
macrophages: 2,524 nCPM
hofbauer cells: 2,336 nCPM
monocytes: 434 nCPM
cdc: 407 nCPM
microglia: 303 nCPM

Immune cell

intermediate monocyte: 143 nTPM
non-classical monocyte: 103 nTPM
total PBMC: 5.3 nTPM
classical monocyte: 1.7 nTPM
myeloid DC: 1.7 nTPM
NK-cell: 0.8 nTPM

Brain region

white matter: 270 nTPM
medulla oblongata: 219 nTPM
thalamus: 178 nTPM
pons: 177 nTPM
spinal cord: 168 nTPM
choroid plexus: 158 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C1QB.

Disease | AllUniProt

Conditions C1QB is implicated in, by any mechanism.

C1q deficiency 2 (C1QD2) MIM:620321

Disease | GeneticClinVar

7 pathogenic / likely-pathogenic of 155 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on C1QB was assayed in.

rheumatoid arthritis B cell
systemic lupus erythematosus B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0.15
gnomAD missense Z: 1.29
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QB as an antibody target. Whether an autoantibody or antibody against C1QB could matter depends on whether native C1QB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QB is annotated at the cell surface, where native C1QB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label C1QB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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