Seroatlas · Human Serome Atlas

EMILIN2

EMILIN-2

Also known as: EMIL2_HUMAN, FLJ33200, FOAP-10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXX0
Gene: EMILIN2
Ensembl: ENSG00000132205
Chromosome: 18
Canonical length: 1053 aa
Protein class: Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix
Quaternary structure: Homotrimer

OverviewNCBI Gene

Predicted to enable extracellular matrix constituent conferring elasticity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of defense response to bacterium; and positive regulation of platelet aggregation. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1053 residues, UniProt reviewed canonical sequence.

>Q9BXX0|EMILIN2
     1  MWQPRRPWPR VPWRWALALL ALVGAGLCHA GPQPGYPARP SARNKNWCAY IVNKNVSCSV
    61  LEGSESFIQA QYNCAWNQMP CPSALVYRVN FRPRYVTRYK TVTQLEWRCC PGFRGGDCQE
   121  GPKDPVKTLR PTPARPRNSL KKATDNEPSQ FSEPRKTLSP TGTAQPSWGV DPKEGPQELQ
   181  EKKIQVLEEK VLRLTRTVLD LQSSLAGVSE NLKHATQDDA SRTRAPGLSS QHPKPDTTVS
   241  GDTETGQSPG VFNTKESGMK DIKSELAEVK DTLKNKSDKL EELDGKVKGY EGQLRQLQEA
   301  AQGPTVTMTT NELYQAYVDS KIDALREELM EGMDRKLADL KNSCEYKLTG LQQQCDDYGS
   361  SYLGVIELIG EKETSLRKEI NNLRARLQEP SAQANCCDSE KNGDIGQQIK TLDQKIERVA
   421  EATRMLNGRL DNEFDRLIVP EPDVDFDAKW NELDARINVT EKNAEEHCFY IEETLRGAIN
   481  GEVGDLKQLV DQKIQSLEDR LGSVLLQMTN NTGAELSPPG AAALPGVSGS GDERVMMELN
   541  HLKDKVQVVE DICLLNIQGK PHGMEGALPN REDRAVRDSL HLLKSLNDTM HRKFQETEQT
   601  IQKLQQDFSF LYSQLNHTEN DVTHLQKEMS NCRAGENAGM GRFTKVGEQE RTVDTLPSPQ
   661  HPVAHCCSQL EERWQRLQSQ VISELDACKE CTQGVQREVS MVEGRVSHME KTCSKLDSIS
   721  GNLQRIKEGL NKHVSSLWNC VRQMNGTLRS HSRDISGLKN SVQQFYSHVF QISTDLQDLV
   781  KFQPSAKAPS PPPPAEAPKE PLQPEPAPPR PSGPATAEDP GRRPVLPQRP PEERPPQPPG
   841  STGVIAETGQ AGPPAGAGVS GRGLPRGVDG QTGSGTVPGA EGFAGAPGYP KSPPVASPGA
   901  PVPSLVSFSA GLTQKPFPSD GGVVLFNKVL VNDGDVYNPS TGVFTAPYDG RYLITATLTP
   961  ERDAYVEAVL SVSNASVAQL HTAGYRREFL EYHRPPGALH TCGGPGAFHL IVHLKAGDAV
  1021  NVVVTGGKLA HTDFDEMYST FSGVFLYPFL SHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMILIN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 72 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 72 nTPM
placenta: 21 nTPM
appendix: 16 nTPM
spinal cord: 14 nTPM
adipose tissue: 12 nTPM
lung: 11 nTPM

Single-cell type

monocytes: 571 nCPM
cdc: 295 nCPM
monocyte progenitors: 263 nCPM
endometrial luminal cells: 242 nCPM
macrophages: 222 nCPM
mast cells: 220 nCPM

Immune cell

basophil: 5.5 nTPM
NK-cell: 1.4 nTPM
classical monocyte: 1.1 nTPM
myeloid DC: 1.1 nTPM
neutrophil: 1.1 nTPM
intermediate monocyte: 0.8 nTPM

Brain region

white matter: 23 nTPM
medulla oblongata: 19 nTPM
thalamus: 18 nTPM
spinal cord: 15 nTPM
pons: 13 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.27
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

extracellular matrix constituent conferring elasticity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EMILIN2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

EMILIN1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMILIN2 as an antibody target. Whether an autoantibody or antibody against EMILIN2 could matter depends on whether native EMILIN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMILIN2 is annotated as secreted, so native EMILIN2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EMILIN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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