Seroatlas · Human Serome Atlas

EMILIN3

EMILIN-3

Also known as: C20orf130, dJ620E11.4, EMIL3_HUMAN, EMILIN5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NT22
Gene
EMILIN3
Ensembl
ENSG00000183798
Chromosome
20
Canonical length
766 aa
Protein class
Predicted secreted proteins
Subcellular location
Golgi apparatus
Secretome location
Secreted to extracellular matrix

OverviewNCBI Gene

Enables identical protein binding activity. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

766 residues, UniProt reviewed canonical sequence.

>Q9NT22|EMILIN3
     1  MGRRRLLVWL CAVAALLSGA QARGTPLLAR PAPPGASRYS LYTTGWRPRL RPGPHKALCA
    61  YVVHRNVTCI LQEGAESYVK AEYRQCRWGP KCPGTVTYRT VLRPKYKVGY KTVTDLAWRC
   121  CPGFTGKRCP EHLTDHGAAS PQLEPEPQIP SGQLDPGPRP PSYSRAAPSP HGRKGPGLFG
   181  ERLERLEGDV QRLAQTYGTL SGLVASHEDP NRMTGGPRAP AVPVGFGVIP EGLVGPGDRA
   241  RGPLTPPLDE ILSKVTEVSN TLQTKVQLLD KVHGLALGHE AHLQRLREAP PSPLTSLALL
   301  EEYVDRRLHR LWGSLLDGFE QKLQGVQSEC DLRVQEVRRQ CEEGQAASRR LHQSLDGREL
   361  ALRQELSQLG SQLQGLSVSG RGSCCGQLAL INARMDGLER ALQAVTETQR GPGAPAGDEL
   421  TRLSAAMLEG GVDGLLEGLE TLNGTEGGAR GCCLRLDMGG WGVGGFGTML EERVQSLEER
   481  LATLAGELSH DSASPGRSAR PLVQTELAVL EQRLVSLETS CTPSTTSAIL DSLVAEVKAW
   541  QSRSEALLRQ VASHAALLQQ LNGTVAEVQG QLAEGTGSSL QGEITLLKVN LNSVSKSLTG
   601  LSDSVSQYSD AFLAANTSLD ERERKVEAEV QAIQEQVSSQ GSRLQAGHRQ VLNLRGELEQ
   661  LKAGVAKVAS GLSRCQDTAQ KLQHTVGHFD QRVAQVEGAC RRLGLLAAGL DSLPTEPLRP
   721  REGLWSHVDQ LNRTLAQHTQ DIARLRDDLL DCQAQLAEQV RPGQAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMILIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 51 nTPM
  • seminal vesicle: 9.4 nTPM
  • cervix: 9.2 nTPM
  • ovary: 8.5 nTPM
  • heart muscle: 8 nTPM
  • prostate: 6.6 nTPM

Single-cell type

  • epicardial cells: 57 nCPM
  • epididymal principal cells: 49 nCPM
  • epididymal efferent duct absorptive cells: 44 nCPM
  • cardiomyocytes: 32 nCPM
  • oligodendrocyte progenitor cells: 20 nCPM
  • endometrial stromal cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 6.3 nTPM
  • medulla oblongata: 6.2 nTPM
  • white matter: 4.7 nTPM
  • pons: 4.5 nTPM
  • midbrain: 3.9 nTPM
  • thalamus: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMILIN3 as an antibody target. Whether an autoantibody or antibody against EMILIN3 could matter depends on whether native EMILIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMILIN3 is annotated as secreted, so native EMILIN3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EMILIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EMILIN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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