Seroatlas · Human Serome Atlas

COL26A1

Collagen alpha-1(XXVI) chain

Also known as: COQA1_HUMAN, EMI6, EMID2, Emu2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A83
Gene: COL26A1
Ensembl: ENSG00000160963
Chromosome: 7
Canonical length: 441 aa
Protein class: Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to extracellular matrix
Quaternary structure: Homotrimer

OverviewNCBI Gene

This gene encodes a protein containing an emilin domain and two collagen stretches. This gene may be associated with aspirin-intolerant asthma. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q96A83|COL26A1
     1  MKLALLLPWA CCCLCGSALA TGFLYPFSAA ALQQHGYPEP GAGSPGSGYA SRRHWCHHTV
    61  TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR PTYRVSYRTV TVLEWRCCPG
   121  FTGSNCDEEC MNCTRLSDMS ERLTTLEAKV LLLEAAERPS SPDNDLPAPE STPPTWNEDF
   181  LPDAIPLAHP VPRQRRPTGP AGPPGQTGPP GPAGPPGSKG DRGQTGEKGP AGPPGLLGPP
   241  GPRGLPGEMG RPGPPGPPGP AGNPGPSPNS PQGALYSLQP PTDKDNGDSR LASAIVDTVL
   301  AGVPGPRGPP GPPGPPGPRG PPGPPGTPGS QGLAGERGTV GPSGEPGVKG EEGEKAATAE
   361  GEGVQQLREA LKILAERVLI LEHMIGIHDP LASPEGGSGQ DAALRANLKM KRGGAQPDGV
   421  LAALLGPDPG QKSVDQASSR K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COL26A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 22 nTPM
hippocampal formation: 9.6 nTPM
kidney: 7.4 nTPM
amygdala: 6.7 nTPM
liver: 5.7 nTPM
basal ganglia: 4.9 nTPM

Single-cell type

pdcs: 198 nCPM
loop of henle epithelial cells: 109 nCPM
brain excitatory neurons: 64 nCPM
differentiating spermatogonia: 50 nCPM
choroid plexus epithelial cells: 36 nCPM
renal collecting duct principal cells: 35 nCPM

Immune cell

plasmacytoid DC: 9.2 nTPM
basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 31 nTPM
hippocampal formation: 24 nTPM
basal ganglia: 19 nTPM
amygdala: 15 nTPM
white matter: 12 nTPM
thalamus: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.83
gnomAD pLI: 0
gnomAD missense Z: 0.18
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of cell-substrate adhesion

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COL26A1 as an antibody target. Whether an autoantibody or antibody against COL26A1 could matter depends on whether native COL26A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COL26A1 is annotated as secreted, so native COL26A1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label COL26A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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