Seroatlas · Human Serome Atlas

C1QTNF3

Complement C1q tumor necrosis factor-related protein 3

Also known as: 2310005P21Rik, C1QT3_HUMAN, Corcs, Cors, Cors-26, CTRP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BXJ4
Gene: C1QTNF3
Ensembl: ENSG00000082196
Chromosome: 5
Canonical length: 246 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Golgi apparatus
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables identical protein binding activity. Involved in several processes, including intracellular triglyceride homeostasis; negative regulation of non-canonical NF-kappaB signal transduction; and regulation of cytokine production. Acts upstream of or within negative regulation of gluconeogenesis. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9BXJ4|C1QTNF3
     1  MLWRQLIYWQ LLALFFLPFC LCQDEYMESP QTGGLPPDCS KCCHGDYSFR GYQGPPGPPG
    61  PPGIPGNHGN NGNNGATGHE GAKGEKGDKG DLGPRGERGQ HGPKGEKGYP GIPPELQIAF
   121  MASLATHFSN QNSGIIFSSV ETNIGNFFDV MTGRFGAPVS GVYFFTFSMM KHEDVEEVYV
   181  YLMHNGNTVF SMYSYEMKGK SDTSSNHAVL KLAKGDEVWL RMGNGALHGD HQRFSTFAGF
   241  LLFETK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 49 nTPM
esophagus: 31 nTPM
retina: 22 nTPM
smooth muscle: 22 nTPM
urinary bladder: 12 nTPM
colon: 11 nTPM

Single-cell type

bergmann glia: 40 nCPM
oligodendrocytes: 32 nCPM
oligodendrocyte progenitor cells: 20 nCPM
choroid plexus epithelial cells: 12 nCPM
astrocytes: 11 nCPM
ependymal cells: 10 nCPM

Immune cell

basophil: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
naive B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

hypothalamus: 11 nTPM
cerebellum: 10 nTPM
spinal cord: 8.3 nTPM
medulla oblongata: 7.2 nTPM
white matter: 6.6 nTPM
basal ganglia: 6.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 1.1
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF3 as an antibody target. Whether an autoantibody or antibody against C1QTNF3 could matter depends on whether native C1QTNF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF3 is annotated as secreted, so native C1QTNF3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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