Seroatlas · Human Serome Atlas

ADIPOQ

Adiponectin

Also known as: ACDC, ACRP30, ADIPO_HUMAN, adiponectin, apM1, GBP28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15848
Gene
ADIPOQ
Ensembl
ENSG00000181092
Chromosome
3
Canonical length
244 aa
Protein class
Candidate cardiovascular disease genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, Transporters
Secretome location
Secreted to blood
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q15848|ADIPOQ
     1  MLLLGAVLLL LALPGHDQET TTQGPGVLLP LPKGACTGWM AGIPGHPGHN GAPGRDGRDG
    61  TPGEKGEKGD PGLIGPKGDI GETGVPGAEG PRGFPGIQGR KGEPGEGAYV YRSAFSVGLE
   121  TYVTIPNMPI RFTKIFYNQQ NHYDGSTGKF HCNIPGLYYF AYHITVYMKD VKVSLFKKDK
   181  AMLFTYDQYQ ENNVDQASGS VLLHLEVGDQ VWLQVYGEGE RNGLYADNDN DSTFTGFLLY
   241  HDTN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ADIPOQ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
843 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 843 nTPM
  • breast: 253 nTPM
  • blood vessel: 51 nTPM
  • tongue: 19 nTPM
  • salivary gland: 18 nTPM
  • adrenal gland: 8.4 nTPM

Single-cell type

  • adipocytes: 483 nCPM
  • fibro-adipogenic progenitors: 13 nCPM
  • cdc: 6.8 nCPM
  • mast cells: 6.8 nCPM
  • mesothelial cells: 3.3 nCPM
  • pericytes: 2.4 nCPM

Immune cell

  • basophil: 0.5 nTPM
  • neutrophil: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • plasmacytoid DC: 0.1 nTPM

Brain region

  • white matter: 2 nTPM
  • cerebellum: 1.8 nTPM
  • cerebral cortex: 1.7 nTPM
  • basal ganglia: 1.6 nTPM
  • choroid plexus: 1.6 nTPM
  • thalamus: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ADIPOQ.

Disease | AllUniProt

Conditions ADIPOQ is implicated in, by any mechanism.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Adiponectin deficiency

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
-0.13
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ADIPOQ in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ADIPOQ as an antibody target. Whether an autoantibody or antibody against ADIPOQ could matter depends on whether native ADIPOQ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ADIPOQ is annotated as secreted, so native ADIPOQ circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label ADIPOQ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ADIPOQ. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...