Seroatlas · Human Serome Atlas

EMID1

EMI domain-containing protein 1

Also known as: EMI5, EMID1_HUMAN, EMU1, hEmu1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96A84
Gene: EMID1
Ensembl: ENSG00000186998
Chromosome: 22
Canonical length: 441 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted in other tissues

OverviewNCBI Gene

Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and extracellular matrix. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

441 residues, UniProt reviewed canonical sequence.

>Q96A84|EMID1
     1  MGGPRAWALL CLGLLLPGGG AAWSIGAAPF SGRRNWCSYV VTRTISCHVQ NGTYLQRVLQ
    61  NCPWPMSCPG SSYRTVVRPT YKVMYKIVTA REWRCCPGHS GVSCEEASSA SLEPMWSGST
   121  MRRMALRPTA FSGCLNCSKV SELTERLKVL EAKMTMLTVI EQPVPPTPAT PEDPAPLWGP
   181  PPAQGSPGDG GLQDQVGAWG LPGPTGPKGD AGSRGPMGMR GPPGPQGPPG SPGRAGAVGT
   241  PGERGPPGPP GPPGPPGPPA PVGPPHARIS QHGDPLLSNT FTETNNHWPQ GPTGPPGPPG
   301  PMGPPGPPGP TGVPGSPGHI GPPGPTGPKG ISGHPGEKGE RGLRGEPGPQ GSAGQRGEPG
   361  PKGDPGEKSH WGEGLHQLRE ALKILAERVL ILETMIGLYE PELGSGAGPA GTGTPSLLRG
   421  KRGGHATNYR IVAPRSRDER G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EMID1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

spleen: 53 nTPM
cerebral cortex: 37 nTPM
amygdala: 34 nTPM
adrenal gland: 31 nTPM
basal ganglia: 25 nTPM
hippocampal formation: 24 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 165 nCPM
astrocytes: 108 nCPM
oligodendrocyte progenitor cells: 105 nCPM
hematopoietic stem cells: 86 nCPM
bergmann glia: 74 nCPM
erythrocyte progenitors: 73 nCPM

Immune cell

NK-cell: 0.4 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 29 nTPM
hippocampal formation: 26 nTPM
basal ganglia: 25 nTPM
amygdala: 24 nTPM
white matter: 20 nTPM
midbrain: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.98
gnomAD pLI: 0
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EMID1 as an antibody target. Whether an autoantibody or antibody against EMID1 could matter depends on whether native EMID1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EMID1 is annotated as secreted, so native EMID1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label EMID1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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