Seroatlas · Human Serome Atlas

C1QTNF5

Complement C1q tumor necrosis factor-related protein 5

Also known as: C1QT5_HUMAN, CTRP5, DKFZp586B0621, LORD

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXJ0
Gene
C1QTNF5
Ensembl
ENSG00000223953
Chromosome
11
Canonical length
243 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Secretome location
Secreted to blood
Quaternary structure
Homotrimer

OverviewNCBI Gene

This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]

Canonical amino-acid sequenceUniProt

243 residues, UniProt reviewed canonical sequence.

>Q9BXJ0|C1QTNF5
     1  MRPLLVLLLL GLAAGSPPLD DNKIPSLCPG HPGLPGTPGH HGSQGLPGRD GRDGRDGAPG
    61  APGEKGEGGR PGLPGPRGDP GPRGEAGPAG PTGPAGECSV PPRSAFSAKR SESRVPPPSD
   121  APLPFDRVLV NEQGHYDAVT GKFTCQVPGV YYFAVHATVY RASLQFDLVK NGESIASFFQ
   181  FFGGWPKPAS LSGGAMVRLE PEDQVWVQVG VGDYIGIYAS IKTDSTFSGF LVYSDWHSSP
   241  VFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C1QTNF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
555 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 555 nTPM
  • blood vessel: 55 nTPM
  • adipose tissue: 50 nTPM
  • gallbladder: 43 nTPM
  • lung: 40 nTPM
  • endometrium: 40 nTPM

Single-cell type

  • choroid plexus epithelial cells: 235 nCPM
  • ependymal cells: 31 nCPM
  • astrocytes: 29 nCPM
  • bergmann glia: 8.4 nCPM
  • oligodendrocyte progenitor cells: 6 nCPM
  • oligodendrocytes: 2.8 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 40 nTPM
  • choroid plexus: 33 nTPM
  • midbrain: 27 nTPM
  • medulla oblongata: 26 nTPM
  • spinal cord: 26 nTPM
  • white matter: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about C1QTNF5.

Disease | AllUniProt

Conditions C1QTNF5 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 206 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.5
gnomAD pLI
0.84
gnomAD missense Z
1.16
DepMap mean gene effect
-0.05
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C1QTNF5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C1QTNF5 as an antibody target. Whether an autoantibody or antibody against C1QTNF5 could matter depends on whether native C1QTNF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C1QTNF5 is annotated as secreted, so native C1QTNF5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label C1QTNF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C1QTNF5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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