Fibroblast growth factor family
IPR002209
Definition
Fibroblast growth factors (FGFs) [[cite:PMID:2549857], [cite:PMID:3072709]] are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [[cite:PMID:1705486], [cite:PMID:8760337]]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [[cite:PMID:11276432], [cite:PMID:23000357], [cite:PMID:15689573], [cite:PMID:10441498], [cite:PMID:23108135], [cite:PMID:23016864]]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [[cite:PMID:1649700], [cite:PMID:11746231], [cite:PMID:14745970], [cite:PMID:8978613]]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) PMID:10830168. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [[cite:PMID:8652550], [cite:PMID:11276432]]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 PMID:7583099, which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active PMID:7583099.
22 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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