Seroatlas · Human Serome Atlas

FGF11

Fibroblast growth factor 11

Also known as: FGF11_HUMAN, FHF3, FLJ16061, MGC102953, MGC45269

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92914
Gene: FGF11
Ensembl: ENSG00000161958
Chromosome: 17
Canonical length: 225 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

225 residues, UniProt reviewed canonical sequence.

>Q92914|FGF11
     1  MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV RLCGGRPARP
    61  DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS FTHFNLIPVG LRVVTIQSAK
   121  LGHYMAMNAE GLLYSSPHFT AECRFKECVF ENYYVLYASA LYRQRRSGRA WYLGLDKEGQ
   181  VMKGNRVKKT KAAAHFLPKL LEVAMYQEPS LHSVPEASPS SPPAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 31 nTPM
esophagus: 20 nTPM
skin: 18 nTPM
vagina: 16 nTPM
heart muscle: 16 nTPM
retina: 14 nTPM

Single-cell type

astrocytes: 17 nCPM
bergmann glia: 8.5 nCPM
oligodendrocyte progenitor cells: 7.7 nCPM
loop of henle epithelial cells: 4.5 nCPM
brain inhibitory neurons: 3.5 nCPM
papillary tip epithelial cells: 1.8 nCPM

Immune cell

eosinophil: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 20 nTPM
thalamus: 20 nTPM
medulla oblongata: 15 nTPM
midbrain: 13 nTPM
basal ganglia: 13 nTPM
pons: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: 0.37
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Growth factor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF11 as an antibody target. Whether an autoantibody or antibody against FGF11 could matter depends on whether native FGF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FGF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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