Seroatlas · Human Serome Atlas

FGF13

Fibroblast growth factor 13

Also known as: FGF13_HUMAN, FGF2, FHF2, FLJ30672, LINC00889

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92913
Gene
FGF13
Ensembl
ENSG00000129682
Chromosome
X
Canonical length
245 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q92913|FGF13
     1  MAAAIASSLI RQKRQARERE KSNACKCVSS PSKGKTSCDK NKLNVFSRVK LFGSKKRRRR
    61  RPEPQLKGIV TKLYSRQGYH LQLQADGTID GTKDEDSTYT LFNLIPVGLR VVAIQGVQTK
   121  LYLAMNSEGY LYTSELFTPE CKFKESVFEN YYVTYSSMIY RQQQSGRGWY LGLNKEGEIM
   181  KGNHVKKNKP AAHFLPKPLK VAMYKEPSLH DLTEFSRSGS GTPTKSRSVS GVLNGGKSMS
   241  HNEST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • hippocampal formation: 65 nTPM
  • amygdala: 53 nTPM
  • skeletal muscle: 52 nTPM
  • cerebral cortex: 52 nTPM
  • basal ganglia: 51 nTPM
  • tongue: 41 nTPM

Single-cell type

  • myonuclei: 946 nCPM
  • distal convoluted tubule cells: 938 nCPM
  • endometrial glandular cells: 817 nCPM
  • prostatic glandular cells: 783 nCPM
  • epididymal clear cells: 741 nCPM
  • salivary acinar cells: 562 nCPM

Immune cell

  • neutrophil: 3.4 nTPM
  • basophil: 1.6 nTPM
  • eosinophil: 0.8 nTPM
  • plasmacytoid DC: 0.4 nTPM
  • classical monocyte: 0.2 nTPM
  • memory B-cell: 0.2 nTPM

Brain region

  • pons: 91 nTPM
  • hippocampal formation: 75 nTPM
  • cerebral cortex: 62 nTPM
  • thalamus: 49 nTPM
  • hypothalamus: 43 nTPM
  • basal ganglia: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF13.

Disease | AllUniProt

Conditions FGF13 is implicated in, by any mechanism.

  • Developmental and epileptic encephalopathy 90 (DEE90) MIM:301058
  • Intellectual developmental disorder, X-linked 110 (XLID110) MIM:301095

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 118 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Developmental and epileptic encephalopathy, 90

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.89
gnomAD missense Z
1.59
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF13 as an antibody target. Whether an autoantibody or antibody against FGF13 could matter depends on whether native FGF13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF13 is annotated at the cell surface, where native FGF13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FGF13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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