Seroatlas · Human Serome Atlas

FGF18

Fibroblast growth factor 18

Also known as: FGF-18, FGF18_HUMAN, ZFGF5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O76093
Gene
FGF18
Ensembl
ENSG00000156427
Chromosome
5
Canonical length
207 aa
Protein class
Cancer-related genes, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in other tissues

OverviewNCBI Gene

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

207 residues, UniProt reviewed canonical sequence.

>O76093|FGF18
     1  MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR
    61  TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP
   121  DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK
   181  GQPELQKPFK YTTVTKRSRR IRPTHPA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 15 nTPM
  • adipose tissue: 4 nTPM
  • skeletal muscle: 3.6 nTPM
  • blood vessel: 2.4 nTPM
  • lung: 2.4 nTPM
  • breast: 2 nTPM

Single-cell type

  • endometrial luminal cells: 62 nCPM
  • breast myoepithelial cells: 41 nCPM
  • endometrial secretory cells: 20 nCPM
  • endometrial glandular cells: 20 nCPM
  • fallopian secretory cells: 18 nCPM
  • mesothelial cells: 17 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 2.9 nTPM
  • pons: 1.9 nTPM
  • medulla oblongata: 1.7 nTPM
  • thalamus: 1.7 nTPM
  • midbrain: 1.3 nTPM
  • basal ganglia: 1.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.39
gnomAD missense Z
2.45
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF18 as an antibody target. Whether an autoantibody or antibody against FGF18 could matter depends on whether native FGF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF18 is annotated as secreted, so native FGF18 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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