Seroatlas · Human Serome Atlas

FGF17

Fibroblast growth factor 17

Also known as: FGF-13, FGF17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60258
Gene
FGF17
Ensembl
ENSG00000158815
Chromosome
8
Canonical length
216 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted secreted proteins, RAS pathway related proteins
Secretome location
Secreted in brain

OverviewNCBI Gene

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>O60258|FGF17
     1  MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR
    61  TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP
   121  SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ
   181  GQLPFPNHAE KQKQFEFVGS APTRRTKRTR RPQPLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGF17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
82 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 82 nTPM
  • cerebral cortex: 24 nTPM
  • hypothalamus: 14 nTPM
  • basal ganglia: 9 nTPM
  • amygdala: 8.7 nTPM
  • hippocampal formation: 7.8 nTPM

Single-cell type

  • brain excitatory neurons: 12 nCPM
  • brain inhibitory neurons: 12 nCPM
  • other brain neurons: 8.6 nCPM
  • cone photoreceptor cells: 8.3 nCPM
  • retinal amacrine cells: 6.3 nCPM
  • retinal bipolar cells: 5.7 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 28 nTPM
  • cerebral cortex: 26 nTPM
  • basal ganglia: 14 nTPM
  • hypothalamus: 13 nTPM
  • white matter: 12 nTPM
  • amygdala: 9.1 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FGF17.

Disease | AllUniProt

Conditions FGF17 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 20 with or without anosmia (HH20) MIM:615270

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 65 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Hypogonadotropic hypogonadism 20 without anosmia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.96
gnomAD missense Z
1.85
DepMap mean gene effect
0.2
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGF17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGF17 as an antibody target. Whether an autoantibody or antibody against FGF17 could matter depends on whether native FGF17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGF17 is annotated as secreted, so native FGF17 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label FGF17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGF17. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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