Seroatlas · Human Serome Atlas

ABI3

ABI gene family member 3

Also known as: ABI3_HUMAN, NESH, SSH3BP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P2A4
Gene
ABI3
Ensembl
ENSG00000108798
Chromosome
17
Canonical length
366 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

366 residues, UniProt reviewed canonical sequence.

>Q9P2A4|ABI3
     1  MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS
    61  VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP
   121  GQKVIAPENL PPLTPYCRRP LNFGCLDDIG HGIKDLSTQL SRTGTLSRKS IKAPATPASA
   181  TLGRPPRIPE PVHLPVVPDG RLSAASSAFS LASAGSAEGV GGAPTPKGQA APPAPPLPSS
   241  LDPPPPPAAV EVFQRPPTLE ELSPPPPDEE LPLPLDLPPP PPLDGDELGL PPPPPGFGPD
   301  EPSWVPASYL EKVVTLYPYT SQKDNELSFS EGTVICVTRR YSDGWCEGVS SEGTGFFPGN
   361  YVEPSC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ABI3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 75 nTPM
  • lymph node: 28 nTPM
  • tonsil: 27 nTPM
  • appendix: 21 nTPM
  • small intestine: 20 nTPM
  • lung: 19 nTPM

Single-cell type

  • kupffer cells: 124 nCPM
  • nk-cells: 81 nCPM
  • macrophages: 68 nCPM
  • monocytes: 63 nCPM
  • cdc: 46 nCPM
  • t-cells: 41 nCPM

Immune cell

  • non-classical monocyte: 793 nTPM
  • intermediate monocyte: 735 nTPM
  • gdT-cell: 291 nTPM
  • myeloid DC: 249 nTPM
  • total PBMC: 234 nTPM
  • memory CD8 T-cell: 189 nTPM

Brain region

  • medulla oblongata: 42 nTPM
  • white matter: 35 nTPM
  • spinal cord: 32 nTPM
  • pons: 32 nTPM
  • thalamus: 29 nTPM
  • hypothalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ABI3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ABI3 as an antibody target. Whether an autoantibody or antibody against ABI3 could matter depends on whether native ABI3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ABI3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ABI3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ABI3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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