Seroatlas · Human Serome Atlas

UBOX5

RING finger protein 37

Also known as: KIAA0860, RNF37, RNF37_HUMAN, Ubce7ip5, UIP5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94941
Gene: UBOX5
Ensembl: ENSG00000185019
Chromosome: 20
Canonical length: 541 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>O94941|UBOX5
     1  MVINLCLPQF RPRIHCNKIS ADGYEVENLI SEDLTKRSHG FRTEYFIKPP VYVTVSFPFN
    61  VEICRINIDL TAGGGQNVTG LEMYTSASSS RVSWNTPQCR TLGPAEPSVP DKEAFTLVGK
   121  VLLKNQSQVV FSHRGFKARP PFGAMEATLP SPAVVAQELW NKGALSLSHV AHLRICITHV
   181  TGGGIPCIKR LEVWGQPAKT CSQEVIDSIL LVTSENLPQD VALQAPALPM ESDCDPGDQP
   241  ESQQAPSSLQ KLAEIIQDVP EEFLDPITLE IMPCPMLLPS GKVIDQSTLE KCNRSEATWG
   301  RVPSDPFTGV AFTPHSQPLP HPSLKARIDH FLLQHSIPGC HLLGRAQTAL AVIPSSIVLP
   361  SQKRKIEQAE HVPDSNFGVN ASCFSATSPL VLPTTSEHTA KKMKATNEPS LTHMDCSTGP
   421  LSHEQKLSQS LEIALASTLG SMPSFTARLT RGQLQHLGTR GSNTSWRPGT GSEQPGSILG
   481  PECASCKRVF SPYFKKEPVY QLPCGHLLCR PCLGEKQRSL PMTCTACQRP VASQDVLRVH
   541  F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against UBOX5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 11 nTPM
skin: 7.6 nTPM
blood vessel: 6.7 nTPM
bone marrow: 6.3 nTPM
cerebellum: 6.3 nTPM
colon: 6.3 nTPM

Single-cell type

myonuclei: 49 nCPM
adipocytes: 28 nCPM
proximal tubule cells: 25 nCPM
choroid plexus epithelial cells: 23 nCPM
cardiomyocytes: 23 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

eosinophil: 9.4 nTPM
neutrophil: 8.1 nTPM
basophil: 7.9 nTPM
memory B-cell: 6.3 nTPM
T-reg: 5.6 nTPM
myeloid DC: 5.5 nTPM

Brain region

white matter: 17 nTPM
cerebellum: 16 nTPM
basal ganglia: 16 nTPM
cerebral cortex: 15 nTPM
hippocampal formation: 14 nTPM
amygdala: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.93
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein polyubiquitination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
U-box domain
Zinc finger, RING/FYVE/PHD-type
Zinc finger, RING-type, conserved site
U-box domain
zinc-RING finger domain
RING finger protein 37
RNF37, RING-Ubox
RING finger protein 37, N-terminal
Family of unknown function (DUF5918)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of UBOX5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads UBOX5 as an antibody target. Whether an autoantibody or antibody against UBOX5 could matter depends on whether native UBOX5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

UBOX5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label UBOX5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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