Seroatlas · Human Serome Atlas

RNF19B

E3 ubiquitin-protein ligase RNF19B

Also known as: FLJ90005, IBRDC3, NKLAM, RN19B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMZ0
Gene: RNF19B
Ensembl: ENSG00000116514
Chromosome: 1
Canonical length: 732 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a multi-pass membrane protein containing two RING-type and one IBR-type zinc finger motifs. The encoded protin is an E3 ubiquitin-protein ligase that plays a role in the cytotoxic effects of natural killer (NK) cells. Alternative splicing results in multiple transcript variants. There are pseudogenes for this gene on chromosomes X and Y in a possible pseudoautosomal region. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

732 residues, UniProt reviewed canonical sequence.

>Q6ZMZ0|RNF19B
     1  MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTLHSVFS ASARGRRARA KPQAEPPPPA
    61  AQPPPAPAPA AAQGPPPEAL PAEPAAEAEA EAAAAAAEPG FDDEEAAEGG GPGAEEVECP
   121  LCLVRLPPER APRLLSCPHR SCRDCLRHYL RLEISESRVP ISCPECSERL NPHDIRLLLA
   181  DPPLMHKYEE FMLRRYLASD PDCRWCPAPD CGYAVIAYGC ASCPKLTCER EGCQTEFCYH
   241  CKQIWHPNQT CDMARQQRAQ TLRVRTKHTS GLSYGQESGP ADDIKPCPRC SAYIIKMNDG
   301  SCNHMTCAVC GCEFCWLCMK EISDLHYLSP SGCTFWGKKP WSRKKKILWQ LGTLIGAPVG
   361  ISLIAGIAIP AMVIGIPVYV GRKIHSRYEG RKTSKHKRNL AITGGVTLSV IASPVIAAVS
   421  VGIGVPIMLA YVYGVVPISL CRGGGCGVST ANGKGVKIEF DEDDGPITVA DAWRALKNPS
   481  IGESSIEGLT SVLSTSGSPT DGLSVMQGPY SETASFAALS GGTLSGGILS SGKGKYSRLE
   541  VQADVQKEIF PKDTASLGAI SDNASTRAMA GSIISSYNPQ DRECNNMEIQ VDIEAKPSHY
   601  QLVSGSSTED SLHVHAQMAE NEEEGSGGGG SEEDPPCRHQ SCEQKDCLAS KPWDISLAQP
   661  ESIRSDLESS DAQSDDVPDI TSDECGSPRS HTAACPSTPR AQGAPSPSAH MNLSALAEGQ
   721  TVLKPEGGEA RV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF19B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 74 nTPM

Expression across tissuesHPA

Tissue

testis: 74 nTPM
bone marrow: 70 nTPM
esophagus: 33 nTPM
tonsil: 29 nTPM
urinary bladder: 28 nTPM
rectum: 24 nTPM

Single-cell type

neutrophils: 1,023 nCPM
monocytes: 239 nCPM
urothelial cells: 198 nCPM
ocular epithelial cells: 149 nCPM
esophageal apical cells: 133 nCPM
epididymal basal cells: 117 nCPM

Immune cell

neutrophil: 17 nTPM
basophil: 6.1 nTPM
eosinophil: 4 nTPM
classical monocyte: 2 nTPM
intermediate monocyte: 1.9 nTPM
non-classical monocyte: 1.7 nTPM

Brain region

cerebellum: 34 nTPM
hypothalamus: 29 nTPM
spinal cord: 29 nTPM
pons: 28 nTPM
white matter: 28 nTPM
thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.35
gnomAD pLI: 0.92
gnomAD missense Z: 2.27
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF19B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF19B as an antibody target. Whether an autoantibody or antibody against RNF19B could matter depends on whether native RNF19B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF19B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF19B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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