Seroatlas · Human Serome Atlas

RNF144A

E3 ubiquitin-protein ligase RNF144A

Also known as: hUIP4, KIAA0161, R144A_HUMAN, RNF144, UBCE7IP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P50876
Gene
RNF144A
Ensembl
ENSG00000151692
Chromosome
2
Canonical length
292 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

292 residues, UniProt reviewed canonical sequence.

>P50876|RNF144A
     1  MTTTRYRPTW DLALDPLVSC KLCLGEYPVE QMTTIAQCQC IFCTLCLKQY VELLIKEGLE
    61  TAISCPDAAC PKQGHLQENE IECMVAAEIM QRYKKLQFER EVLFDPCRTW CPASTCQAVC
   121  QLQDVGLQTP QPVQCKACRM EFCSTCKASW HPGQGCPETM PITFLPGETS AAFKMEEDDA
   181  PIKRCPKCKV YIERDEGCAQ MMCKNCKHAF CWYCLESLDD DFLLIHYDKG PCRNKLGHSR
   241  ASVIWHRTQV VGIFAGFGLL LLVASPFLLL ATPFVLCCKC KCSKGDDDPL PT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF144A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
55 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 55 nTPM
  • parathyroid gland: 36 nTPM
  • pancreas: 29 nTPM
  • spinal cord: 28 nTPM
  • adrenal gland: 27 nTPM
  • basal ganglia: 25 nTPM

Single-cell type

  • cone photoreceptor cells: 681 nCPM
  • oligodendrocytes: 494 nCPM
  • rod photoreceptor cells: 490 nCPM
  • gonadotrophs: 358 nCPM
  • oligodendrocyte progenitor cells: 355 nCPM
  • adrenal cortex cells: 308 nCPM

Immune cell

  • eosinophil: 6.1 nTPM
  • naive CD4 T-cell: 2.4 nTPM
  • MAIT T-cell: 1.8 nTPM
  • naive CD8 T-cell: 1.7 nTPM
  • memory CD4 T-cell: 1.3 nTPM
  • basophil: 1.2 nTPM

Brain region

  • white matter: 179 nTPM
  • cerebellum: 156 nTPM
  • basal ganglia: 128 nTPM
  • pons: 103 nTPM
  • cerebral cortex: 102 nTPM
  • medulla oblongata: 96 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.95
gnomAD missense Z
1.44
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF144A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF144A as an antibody target. Whether an autoantibody or antibody against RNF144A could matter depends on whether native RNF144A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF144A is annotated at the cell surface, where native RNF144A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RNF144A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF144A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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