Seroatlas · Human Serome Atlas

RNF19A

E3 ubiquitin-protein ligase RNF19A

Also known as: DKFZp566B1346, dorfin, RN19A_HUMAN, RNF19

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NV58
Gene: RNF19A
Ensembl: ENSG00000034677
Chromosome: 8
Canonical length: 838 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the ring between ring fingers (RBR) protein family, and the encoded protein contains two RING-finger motifs and an in between RING fingers motif. This protein is an E3 ubiquitin ligase that is localized to Lewy bodies, and ubiquitylates synphilin-1, which is an interacting protein of alpha synuclein in neurons. The encoded protein may be involved in amyotrophic lateral sclerosis and Parkinson's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

838 residues, UniProt reviewed canonical sequence.

>Q9NV58|RNF19A
     1  MQEQEIGFIS KYNEGLCVNT DPVSILTSIL DMSLHRQMGS DRDLQSSASS VSLPSVKKAP
    61  KKRRISIGSL FRRKKDNKRK SRELNGGVDG IASIESIHSE MCTDKNSIFS TNTSSDNGLT
   121  SISKQIGDFI ECPLCLLRHS KDRFPDIMTC HHRSCVDCLR QYLRIEISES RVNISCPECT
   181  ERFNPHDIRL ILSDDVLMEK YEEFMLRRWL VADPDCRWCP APDCGYAVIA FGCASCPKLT
   241  CGREGCGTEF CYHCKQIWHP NQTCDAARQE RAQSLRLRTI RSSSISYSQE SGAAADDIKP
   301  CPRCAAYIIK MNDGSCNHMT CAVCGCEFCW LCMKEISDLH YLSPSGCTFW GKKPWSRKKK
   361  ILWQLGTLVG APVGIALIAG IAIPAMIIGI PVYVGRKIHN RYEGKDVSKH KRNLAIAGGV
   421  TLSVIVSPVV AAVTVGIGVP IMLAYVYGVV PISLCRSGGC GVSAGNGKGV RIEFDDENDI
   481  NVGGTNTAVD TTSVAEARHN PSIGEGSVGG LTGSLSASGS HMDRIGAIRD NLSETASTMA
   541  LAGASITGSL SGSAMVNCFN RLEVQADVQK ERYSLSGESG TVSLGTVSDN ASTKAMAGSI
   601  LNSYIPLDKE GNSMEVQVDI ESKPSKFRHN SGSSSVDDGS ATRSHAGGSS SGLPEGKSSA
   661  TKWSKEATAG KKSKSGKLRK KGNMKINETR EDMDAQLLEQ QSTNSSEFEA PSLSDSMPSV
   721  ADSHSSHFSE FSCSDLESMK TSCSHGSSDY HTRFATVNIL PEVENDRLEN SPHQCSISVV
   781  TQTASCSEVS QLNHIAEEHG NNGIKPNVDL YFGDALKETN NNHSHQTMEL KVAIQTEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF19A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 54 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 54 nTPM
lymph node: 52 nTPM
testis: 50 nTPM
cervix: 49 nTPM
liver: 46 nTPM
tonsil: 41 nTPM

Single-cell type

endometrial glandular cells: 1,005 nCPM
urothelial cells: 897 nCPM
t-cells: 702 nCPM
innate lymphoid cells: 563 nCPM
endometrial ciliated cells: 483 nCPM
pancreatic duct cells: 445 nCPM

Immune cell

basophil: 27 nTPM
neutrophil: 20 nTPM
gdT-cell: 16 nTPM
memory B-cell: 16 nTPM
T-reg: 15 nTPM
non-classical monocyte: 14 nTPM

Brain region

hypothalamus: 112 nTPM
medulla oblongata: 94 nTPM
white matter: 91 nTPM
thalamus: 88 nTPM
spinal cord: 88 nTPM
midbrain: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.03
gnomAD missense Z: 2.38
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF19A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF19A as an antibody target. Whether an autoantibody or antibody against RNF19A could matter depends on whether native RNF19A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF19A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF19A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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