ARIH1

Protein identityUniProt · HPA

UniProt accession

Q9Y4X5

Gene

ARIH1

Ensembl

ENSG00000166233

Chromosome

15

Canonical length

557 aa

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nucleoplasm

OverviewNCBI Gene

Enables enzyme binding activity; ubiquitin-protein transferase activity; and zinc ion binding activity. Involved in protein ubiquitination. Located in several cellular components, including Lewy body; cullin-RING ubiquitin ligase complex; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>Q9Y4X5|ARIH1
     1  MDSDEGYNYE FDEDEECSEE DSGAEEEEDE DDDEPDDDTL DLGEVELVEP GLGVGGERDG
    61  LLCGETGGGG GSALGPGGGG GGGGGGGGGG PGHEQEEDYR YEVLTAEQIL QHMVECIREV
   121  NEVIQNPATI TRILLSHFNW DKEKLMERYF DGNLEKLFAE CHVINPSKKS RTRQMNTRSS
   181  AQDMPCQICY LNYPNSYFTG LECGHKFCMQ CWSEYLTTKI MEEGMGQTIS CPAHGCDILV
   241  DDNTVMRLIT DSKVKLKYQH LITNSFVECN RLLKWCPAPD CHHVVKVQYP DAKPVRCKCG
   301  RQFCFNCGEN WHDPVKCKWL KKWIKKCDDD SETSNWIAAN TKECPKCHVT IEKDGGCNHM
   361  VCRNQNCKAE FCWVCLGPWE PHGSAWYNCN RYNEDDAKAA RDAQERSRAA LQRYLFYCNR
   421  YMNHMQSLRF EHKLYAQVKQ KMEEMQQHNM SWIEVQFLKK AVDVLCQCRA TLMYTYVFAF
   481  YLKKNNQSII FENNQADLEN ATEVLSGYLE RDISQDSLQD IKQKVQDKYR YCESRRRVLL
   541  QHVHEGYEKD LWEYIED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARIH1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

45 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.17

gnomAD pLI

1

gnomAD missense Z

4.59

DepMap mean gene effect

-1.4

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• PKR/eIFalpha signaling
• protein ubiquitination
• ubiquitin-dependent protein catabolic process

Molecular functions

• ubiquitin conjugating enzyme binding
• ubiquitin protein ligase activity
• ubiquitin protein ligase binding
• ubiquitin-like protein transferase activity
• ubiquitin-protein transferase activity
• zinc ion binding

Cellular components

• Cajal body
• cytoplasm
• cytosol
• Lewy body
• nuclear body
• nucleoplasm
• nucleus
• ubiquitin ligase complex

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, RING-type
• IBR domain
• Zinc finger, RING/FYVE/PHD-type
• Zinc finger, C3HC4 RING-type
• E3 ubiquitin ligase RBR family
• TRIAD supradomain
• Ariadne domain
• Zinc finger, C3HC4 type (RING finger)
• IBR domain, a half RING-finger domain
• Ariadne domain
• IBR domain
• E3 ubiquitin-protein ligase ARIH1-like, UBA-like domain
• E3 ubiquitin-protein ligase ARIH1, UBA-like domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Metal-binding
• Nucleus
• Repeat
• Transferase
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of ARIH1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBE2L3
• CUL1