Seroatlas · Human Serome Atlas

CCNB1IP1

E3 ubiquitin-protein ligase CCNB1IP1

Also known as: C14orf18, CIP1_HUMAN, HEI10

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPC3
Gene: CCNB1IP1
Ensembl: ENSG00000100814
Chromosome: 14
Canonical length: 277 aa
Protein class: Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

277 residues, UniProt reviewed canonical sequence.

>Q9NPC3|CCNB1IP1
     1  MSLCEDMLLC NYRKCRIKLS GYAWVTACSH IFCDQHGSGE FSRSPAICPA CNSTLSGKLD
    61  IVRTELSPSE EYKAMVLAGL RPEIVLDISS RALAFWTYQV HQERLYQEYN FSKAEGHLKQ
   121  MEKIYTQQIQ SKDVELTSMK GEVTSMKKVL EEYKKKFSDI SEKLMERNRQ YQKLQGLYDS
   181  LRLRNITIAN HEGTLEPSMI AQSGVLGFPL GNNSKFPLDN TPVRNRGDGD GDFQFRPFFA
   241  GSPTAPEPSN SFFSFVSPSR ELEQQQVSSR AFKVKRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNB1IP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 100 nTPM

Expression across tissuesHPA

Tissue

ovary: 100 nTPM
choroid plexus: 85 nTPM
liver: 70 nTPM
heart muscle: 70 nTPM
kidney: 62 nTPM
tongue: 59 nTPM

Single-cell type

cardiomyocytes: 453 nCPM
oocytes: 263 nCPM
late spermatids: 169 nCPM
ovarian stromal cells: 130 nCPM
early primary spermatocytes: 120 nCPM
migrating cytotrophoblasts: 93 nCPM

Immune cell

plasmacytoid DC: 18 nTPM
myeloid DC: 18 nTPM
T-reg: 13 nTPM
naive CD8 T-cell: 13 nTPM
memory B-cell: 12 nTPM
MAIT T-cell: 11 nTPM

Brain region

choroid plexus: 29 nTPM
hypothalamus: 23 nTPM
pons: 22 nTPM
white matter: 21 nTPM
cerebral cortex: 19 nTPM
spinal cord: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0
gnomAD missense Z: 1.07
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

synaptonemal complex

Protein domainsUniProt · Pfam · InterPro

Zinc finger, RING-type
zinc-RING finger domain
E3 ubiquitin-protein ligase CCNB1IP1

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCNB1IP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNB1IP1 as an antibody target. Whether an autoantibody or antibody against CCNB1IP1 could matter depends on whether native CCNB1IP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNB1IP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNB1IP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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