Seroatlas · Human Serome Atlas

RNF144B

E3 ubiquitin-protein ligase RNF144B

Also known as: bA528A10.3, IBRDC2, P53RFP, R144B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z419
Gene: RNF144B
Ensembl: ENSG00000137393
Chromosome: 6
Canonical length: 303 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

Enables ubiquitin-protein transferase activity. Involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Located in mitochondrial membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q7Z419|RNF144B
     1  MGSAGRLHYL AMTAENPTPG DLAPAPLITC KLCLCEQSLD KMTTLQECQC IFCTACLKQY
    61  MQLAIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDQF QLYQRLKFER EVHLDPYRTW
   121  CPVADCQTVC PVASSDPGQP VLVECPSCHL KFCSCCKDAW HAEVSCRDSQ PIVLPTEHRA
   181  LFGTDAEAPI KQCPVCRVYI ERNEGCAQMM CKNCKHTFCW YCLQNLDNDI FLRHYDKGPC
   241  RNKLGHSRAS VMWNRTQVVG ILVGLGIIAL VTSPLLLLAS PCIICCVCKS CRGKKKKHDP
   301  STT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF144B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 53 nTPM
thyroid gland: 38 nTPM
breast: 27 nTPM
bone marrow: 23 nTPM
skin: 20 nTPM
lung: 18 nTPM

Single-cell type

neutrophils: 3,934 nCPM
suprabasal keratinocytes: 1,427 nCPM
monocytes: 1,203 nCPM
basal keratinocytes: 705 nCPM
cdc: 614 nCPM
macrophages: 522 nCPM

Immune cell

non-classical monocyte: 72 nTPM
intermediate monocyte: 39 nTPM
neutrophil: 37 nTPM
classical monocyte: 21 nTPM
plasmacytoid DC: 18 nTPM
myeloid DC: 13 nTPM

Brain region

midbrain: 20 nTPM
medulla oblongata: 19 nTPM
thalamus: 17 nTPM
pons: 14 nTPM
choroid plexus: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.53
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF144B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF144B as an antibody target. Whether an autoantibody or antibody against RNF144B could matter depends on whether native RNF144B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF144B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF144B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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