Seroatlas · Human Serome Atlas

TXLNG

Gamma-taxilin

Also known as: CXorf15, FIAT, FLJ11209, LSR5, MGC126621, MGC126625, TXLNG_HUMAN, TXLNGX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NUQ3
Gene: TXLNG
Ensembl: ENSG00000086712
Chromosome: X
Canonical length: 528 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the taxilin family. The encoded protein binds to the C-terminal coiled-coil region of syntaxin family members 1A, 3A and 4A, and may play a role in intracellular vesicle trafficking. This gene is up-regulated by lipopolysaccharide and the gene product may be involved in cell cycle regulation. The related mouse protein was also shown to inhibit activating transcription factor 4-mediated transcription and thus regulate bone mass accrual. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

528 residues, UniProt reviewed canonical sequence.

>Q9NUQ3|TXLNG
     1  MATRVEEAAR GRGGGAEEAT EAGRGGRRRS PRQKFEIGTM EEAGICGLGV KADMLCNSQS
    61  NDILQHQGSN CGGTSNKHSL EEDEGSDFIT ENRNLVSPAY CTQESREEIP GGEARTDPPD
   121  GQQDSECNRN KEKTLGKEVL LLMQALNTLS TPEEKLAALC KKYADLLEES RSVQKQMKIL
   181  QKKQAQIVKE KVHLQSEHSK AILARSKLES LCRELQRHNK TLKEENMQQA REEEERRKEA
   241  TAHFQITLNE IQAQLEQHDI HNAKLRQENI ELGEKLKKLI EQYALREEHI DKVFKHKELQ
   301  QQLVDAKLQQ TTQLIKEADE KHQREREFLL KEATESRHKY EQMKQQEVQL KQQLSLYMDK
   361  FEEFQTTMAK SNELFTTFRQ EMEKMTKKIK KLEKETIIWR TKWENNNKAL LQMAEEKTVR
   421  DKEYKALQIK LERLEKLCRA LQTERNELNE KVEVLKEQVS IKAAIKAANR DLATPVMQPC
   481  TALDSHKELN TSSKRALGAH LEAEPKSQRS AVQKPPSTGS APAIESVD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TXLNG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 15 nTPM
retina: 14 nTPM
adipose tissue: 14 nTPM
bone marrow: 14 nTPM
ovary: 12 nTPM
lymph node: 12 nTPM

Single-cell type

somatotrophs: 139 nCPM
pituicytes/fscs: 111 nCPM
salivary myoepithelial cells: 100 nCPM
oocytes: 97 nCPM
adrenal cortex cells: 95 nCPM
t-cells: 92 nCPM

Immune cell

naive CD8 T-cell: 4.4 nTPM
naive B-cell: 4.1 nTPM
MAIT T-cell: 4 nTPM
naive CD4 T-cell: 4 nTPM
T-reg: 3.8 nTPM
memory B-cell: 3.7 nTPM

Brain region

cerebellum: 20 nTPM
choroid plexus: 18 nTPM
white matter: 16 nTPM
hypothalamus: 16 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 0.09
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TXLNG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TXLNA

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TXLNG as an antibody target. Whether an autoantibody or antibody against TXLNG could matter depends on whether native TXLNG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TXLNG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TXLNG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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